Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

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http://www.wikidata.org/entity/Q27644556
The azaindole framework in the design of kinase inhibitorsDiscovery of 4-Amino-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB MimicAkt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plantsQuantum mechanical pairwise decomposition analysis of protein kinase B inhibitors: validating a new tool for guiding drug designAkt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effectsMultiple roles and therapeutic implications of Akt signaling in cancer.Discovery of a selective, safe and novel anti-malarial compound with activity against chloroquine resistant strain of Plasmodium falciparum.Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930.A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth.Theory of docking scores and its application to a customizable scoring function.Evaluating the enthalpic contribution to ligand binding using QM calculations: effect of methodology on geometries and interaction energies.
P2860

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

Item
http://www.wikidata.org/entity/Q27644556
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2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年学术文章
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2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Rapid evolution of 6-phenylpur ...... through structure-based design
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Rapid evolution of 6-phenylpur ...... through structure-based design
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Rapid evolution of 6-phenylpur ...... through structure-based design
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type
label
Rapid evolution of 6-phenylpur ...... through structure-based design
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Rapid evolution of 6-phenylpur ...... through structure-based design
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Rapid evolution of 6-phenylpur ...... through structure-based design
@nl
prefLabel
Rapid evolution of 6-phenylpur ...... through structure-based design
@ast
Rapid evolution of 6-phenylpur ...... through structure-based design
@en
Rapid evolution of 6-phenylpur ...... through structure-based design
@nl
P1433
P1476
P2093
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P3181
P356
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P433
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P577
P698
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P3181
P356
P1433
P1476
Rapid evolution of 6-phenylpur ...... through structure-based design
@en
P2093
P304
P31
P3181
P356
P407
P433
P478
P577
P698
P921