Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors - Wikidata - wikimedia - TriplyDB

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

http://www.wikidata.org/entity/Q27646508

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The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets Structure analysis reveals the flexibility of the ADAMTS-5 active site Roles of microRNA and signaling pathway in osteoarthritis pathogenesis The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice.Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.Proteases involved in cartilage matrix degradation in osteoarthritis.Advances in the development of novel aggrecanase inhibitors.MicroRNA in osteoarthritis.Are we moving in the right direction with osteoarthritis drug discovery?Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis.Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.Cytokine secretion and NK cell activity in human ADAM17 deficiency.Computational Insights into ADAMTS4, ADAMTS5 and MMP13 Inhibitor Selectivity.The murine goblet cell protein mCLCA3 is a zinc-dependent metalloprotease with autoproteolytic activity.ADAMTS5 deficiency protects against non-alcoholic steatohepatitis in obesity.Regional intravenous limb perfusion compared to systemic intravenous administration for marimastat delivery to equine lamellar tissue.

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Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

http://www.wikidata.org/entity/Q27646508

description

2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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JBC.M109.029116

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Journal of Biological Chemistry

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Structural and Inhibition Anal ...... ries of Aggrecanase Inhibitors

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Alfredo G Tomasselli

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Anne-Marie Malfait

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Arthur J Wittwer

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Grace Munie

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Huey-Sheng Shieh

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Jennifer M Williams

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Karl J Mathis

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Mark E Schnute

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Micky D Tortorella

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Nicole Caspers

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P2860

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.

The futility of current approaches to chondroprotection.

Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.

Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.

Potent P1' biphenylmethyl substituted aggrecanase inhibitors.

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10.1074/JBC.M109.029116

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36

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