Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.
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C17 prevents inflammatory arthritis and associated joint destruction in miceThe ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familyDecreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulationA transcriptional enhancer from the coding region of ADAMTS5Regulation of secreted Frizzled-related protein-1 by heparinExtracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathwaysInhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulinADAMTS-12 associates with and degrades cartilage oligomeric matrix proteinSodium and T1rho MRI for molecular and diagnostic imaging of articular cartilageA disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanismsCrystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.Cellular ageing mechanisms in osteoarthritisOn the predictive utility of animal models of osteoarthritisAdvances in understanding cartilage remodelingBiomarkers of Chondrocyte Apoptosis and Autophagy in OsteoarthritisGenetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug TargetsOsteoarthritis pathogenesis: a review of molecular mechanismsExpression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degenerationBiomechanical factors in osteoarthritisMelanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritisCurcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse modelStructural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase InhibitorsHigh resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)Structure analysis reveals the flexibility of the ADAMTS-5 active siteBiochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities.Insights on Molecular Mechanisms of Chondrocytes Death in OsteoarthritisArticular Cartilage: Structural and Developmental Intricacies and QuestionsThe microRNA-29 family in cartilage homeostasis and osteoarthritisO-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamilyIntegrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networksO-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulationAging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritisMolecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminencesNon-Invasive Quantification of Cartilage Using a Novel In Vivo Bioluminescent Reporter MouseADAMTS5 Is a Critical Regulator of Virus-Specific T Cell ImmunityThe secreted metalloprotease ADAMTS20 is required for melanoblast survivalChondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolismBiosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase
P2860
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P2860
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@ast
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@en
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@nl
type
label
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@ast
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@en
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@nl
prefLabel
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@ast
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@en
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@nl
P2093
P356
P1433
P1476
Deletion of active ADAMTS5 pre ...... urine model of osteoarthritis.
@en
P2093
Barbara Sheppard
Brenda Carito
Carl R Flannery
Diane Peluso
Elisabeth A Morris
Hak-Ling Ma
Manas K Majumdar
Roger Askew
Sonya S Glasson
P2888
P304
P356
10.1038/NATURE03369
P407
P577
2005-03-01T00:00:00Z
P5875
P6179
1026274540