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Identification of PP2A complexes and pathways involved in cell transformationHuman Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulatorThe Ancient Evolutionary History of PolyomavirusesStructure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau DephosphorylationStructural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2ADefect of insulin signal in peripheral tissues: Important role of ceramideTBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activityActivation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats.JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activityA protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development.Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7.Complex energy landscape of a giant repeat protein.Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification.Phosphatases: the new brakes for cancer development?Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen.p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation.The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA ReplicationPP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in CancerCardiomyocyte specific deletion of PP2A causes cardiac hypertrophy.Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response.PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigenImpaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway.Ligand binding by repeat proteins: natural and designed.Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein.Release from meiotic arrest in ascidian eggs requires the activity of two phosphatases but not CaMKIILessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.Roles of phosphotase 2A in nociceptive signal processing.Assembly and structure of protein phosphatase 2A.Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development.Functions of B56-containing PP2As in major developmental and cancer signaling pathways.The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification.All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.Human JC virus small tumour antigen inhibits nucleotide excision repair and sensitises cells to DNA-damaging agents.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structural Basis of PP2A Inhibition by Small t Antigen
@ast
Structural Basis of PP2A Inhibition by Small t Antigen
@en
Structural Basis of PP2A Inhibition by Small t Antigen
@nl
type
label
Structural Basis of PP2A Inhibition by Small t Antigen
@ast
Structural Basis of PP2A Inhibition by Small t Antigen
@en
Structural Basis of PP2A Inhibition by Small t Antigen
@nl
prefLabel
Structural Basis of PP2A Inhibition by Small t Antigen
@ast
Structural Basis of PP2A Inhibition by Small t Antigen
@en
Structural Basis of PP2A Inhibition by Small t Antigen
@nl
P2093
P2860
P50
P3181
P1433
P1476
Structural Basis of PP2A Inhibition by Small t Antigen
@en
P2093
Seamus Morrone
Uhn Soo Cho
William C Hahn
P2860
P3181
P356
10.1371/JOURNAL.PBIO.0050202
P407
P577
2007-08-01T00:00:00Z