Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. - Wikidata - wikimedia - TriplyDB

Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7.

Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7.

http://www.wikidata.org/entity/Q34364753

about

Oncogenes and RNA splicing of human tumor viruses The conundrum of causality in tumor virology: the cases of KSHV and MCV Mutational analysis of merkel cell carcinoma Viruses and human cancers: a long road of discovery of molecular paradigms.Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus.Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice.Large T and small T antigens of Merkel cell polyomavirus.BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo.Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice.CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen.Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA Replication Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens.The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen.Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas.Merkel cell polyomavirus infection and Merkel cell carcinoma.Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration.Merkel cell polyomavirus small T antigen targets the NEMO adaptor protein to disrupt inflammatory signaling Entry, infection, replication, and egress of human polyomaviruses: an update.How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model.RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy.Merkel cell polyomavirus and Merkel cell carcinoma.Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting.Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in Mice.Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence.Spontaneous lung metastasis formation of human Merkel cell carcinoma cell lines transplanted into scid mice.Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study.Prognostic value of antibodies to Merkel cell polyomavirus T antigens and VP1 protein in patients with Merkel cell carcinoma.The T antigen locus of Merkel cell polyomavirus downregulates human Toll-like receptor 9 expression.Merkel cell polyomavirus-positive Merkel cell carcinoma requires viral small T-antigen for cell proliferation.Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.Merkel Cell Polyomavirus: A New DNA Virus Associated with Human Cancer.Human Polyomaviruses: The Battle of Large and Small Tumor Antigens.Merkel cell carcinoma in the age of immunotherapy: Facts and hopes.Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-dependent Protein Degradation.

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P2860

Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7.

http://www.wikidata.org/entity/Q34364753

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

@ast

Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

@en

Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

@nl

type

label

Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

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Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

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Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

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prefLabel

Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

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Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

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Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

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P356

J.CHOM.2013.06.008

P1433

Cell Host & Microbe

P1476

Merkel cell polyomavirus small ...... ular ubiquitin ligase SCFFbw7.

@en

P2093

Carlos J Camacho

http://www.w3.org/2001/XMLSchema#string

Huichen Feng

http://www.w3.org/2001/XMLSchema#string

P2860

Cellular and viral factors regulating Merkel cell polyomavirus replication

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator

T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

Clonal integration of a polyomavirus in human Merkel cell carcinoma

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

Structural Basis of PP2A Inhibition by Small t Antigen

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125-135

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scholarly article

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10.1016/J.CHOM.2013.06.008

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2

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14

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Patrick S Moore

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2013-08-01T00:00:00Z

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255974351

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23954152

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3764649

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