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Conformational flexibility in the flap domains of ligand-free HIV protease

Conformational flexibility in the flap domains of ligand-free HIV protease

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Charting a Path to Success in Virtual Screening Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance.Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes Fragment-Based Screen against HIV Protease PagP Crystallized from SDS/Cosolvent Reveals the Route for Phospholipid Access to the Hydrocarbon Ruler Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants Capturing the Reaction Pathway in Near-Atomic-Resolution Crystal Structures of HIV-1 Protease Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds Structures of Darunavir-Resistant HIV-1 Protease Mutant Reveal Atypical Binding of Darunavir to Wide Open Flaps Evidence that the Bacillus subtilis SpoIIGA protein is a novel type of signal-transducing aspartic protease Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics Flap dynamics of plasmepsin proteases: insight into proposed parameters and molecular dynamics Understanding HIV-1 protease autoprocessing for novel therapeutic development.Mining the protein data bank to differentiate error from structural variation in clustered static structures: an examination of HIV protease.Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease.Conformation of inhibitor-free HIV-1 protease derived from NMR spectroscopy in a weakly oriented solution Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation.Conformational variation of an extreme drug resistant mutant of HIV protease.Modelling dynamics in protein crystal structures by ensemble refinement Pulsed EPR characterization of HIV-1 protease conformational sampling and inhibitor-induced population shifts.Switches of hydrogen bonds during ligand-protein association processes determine binding kinetics.Atomistic simulations of the HIV-1 protease folding inhibition.Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations.Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS Enhanced conformational sampling technique provides an energy landscape view of large-scale protein conformational transitions.Dataset showing the impact of the protonation states on molecular dynamics of HIV protease.A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant.Developing HIV-1 Protease Inhibitors through Stereospecific Reactions in Protein Crystals.Flap flexibility amongst plasmepsins I, II, III, IV, and V: Sequence, structural, and molecular dynamics analyses.MFPred: Rapid and accurate prediction of protein-peptide recognition multispecificity using self-consistent mean field theory.Crystallisation of wild-type and variant forms of a recombinant plant enzyme β-D-glucan glucohydrolase from barley (Hordeum vulgare L.) and preliminary X-ray analysis.Subtype polymorphisms among HIV-1 protease variants confer altered flap conformations and flexibility.Elucidating a relationship between conformational sampling and drug resistance in HIV-1 protease.Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights.Amide hydrogen exchange in HIV-1 subtype B and C proteases--insights into reduced drug susceptibility and dimer stability.Effects of PRE and POST therapy drug-pressure selected mutations on HIV-1 protease conformational sampling.

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P2860

Conformational flexibility in the flap domains of ligand-free HIV protease

http://www.wikidata.org/entity/Q27646822

description

2007 nî lūn-bûn

@nan

2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2007年の論文

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2007年論文

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2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

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name

Conformational flexibility in the flap domains of ligand-free HIV protease

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Conformational flexibility in the flap domains of ligand-free HIV protease

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Conformational flexibility in the flap domains of ligand-free HIV protease

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type

label

Conformational flexibility in the flap domains of ligand-free HIV protease

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Conformational flexibility in the flap domains of ligand-free HIV protease

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Conformational flexibility in the flap domains of ligand-free HIV protease

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prefLabel

Conformational flexibility in the flap domains of ligand-free HIV protease

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Conformational flexibility in the flap domains of ligand-free HIV protease

@en

Conformational flexibility in the flap domains of ligand-free HIV protease

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Acta Crystallographica Section D: Biological Crystallography

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Conformational flexibility in the flap domains of ligand-free HIV protease

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P2093

Bruce E Torbett

http://www.w3.org/2001/XMLSchema#string

C David Stout

http://www.w3.org/2001/XMLSchema#string

Duncan E McRee

http://www.w3.org/2001/XMLSchema#string

Holly Heaslet

http://www.w3.org/2001/XMLSchema#string

John H Elder

http://www.w3.org/2001/XMLSchema#string

Karen Tam

http://www.w3.org/2001/XMLSchema#string

Mike Giffin

http://www.w3.org/2001/XMLSchema#string

Robin Rosenfeld

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Ying Chuan Lin

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866-75

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scholarly article

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4411079

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10.1107/S0907444907029125

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Pt 8

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63

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2007-08-01T00:00:00Z

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17642513

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