Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
about
Molecular targets for flavivirus drug discoveryIdentification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzymeStructure and functionality in flavivirus NS-proteins: perspectives for drug designStructural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus MethyltransferaseMaturation of dengue virus nonstructural protein 4B in monocytes enhances production of dengue hemorrhagic fever-associated chemokines and cytokinesInhibitor designing, virtual screening, and docking studies for methyltransferase: A potential target against dengue virusFunctions of the 3' and 5' genome RNA regions of members of the genus FlavivirusSTAT2 signaling and dengue virus infectionA crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replicationThe C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus ProductionStructural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferaseWest Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning MechanismSeparate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA capPhosphorylation of yellow fever virus NS5 alters methyltransferase activityAnalysis of Flavivirus NS5 Methyltransferase Cap BindingThe flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structureCrystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral ReplicationFocus on flaviviruses: current and future drug targetsCrystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNACrystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 ComplexBiochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein ComplexStructural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formationThe FDA-approved drug sofosbuvir inhibits Zika virus infectionStructures of NS5 Methyltransferase from Zika VirusRNA methyltransferases involved in 5' cap biosynthesisThe Zika virus methyltransferase: structure and functions for drug design perspectivesIn vitro reconstitution of SARS-coronavirus mRNA cap methylationMurine Efficacy and Pharmacokinetic Evaluation of the Flaviviral NS5 Capping Enzyme 2-Thioxothiazolidin-4-One Inhibitor BG-323Perturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongationThe crystal structure of Zika virus NS5 reveals conserved drug targetsBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondPotential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses.Current progress in dengue vaccinesModification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation.Substitution of NS5 N-terminal domain of dengue virus type 2 RNA with type 4 domain caused impaired replication and emergence of adaptive mutants with enhanced fitness.Circulation of different lineages of dengue virus type 2 in Central America, their evolutionary time-scale and selection pressure analysis.Molecular basis for nucleotide conservation at the ends of the dengue virus genome.The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replicationFlavivirus RNA cap methyltransferase: structure, function, and inhibition.Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface
P2860
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P2860
Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structural and functional anal ...... ase domain of dengue virus NS5
@ast
Structural and functional anal ...... ase domain of dengue virus NS5
@en
Structural and functional anal ...... ase domain of dengue virus NS5
@nl
type
label
Structural and functional anal ...... ase domain of dengue virus NS5
@ast
Structural and functional anal ...... ase domain of dengue virus NS5
@en
Structural and functional anal ...... ase domain of dengue virus NS5
@nl
altLabel
Structural and Functional Anal ...... ase Domain of Dengue Virus NS5
@en
prefLabel
Structural and functional anal ...... ase domain of dengue virus NS5
@ast
Structural and functional anal ...... ase domain of dengue virus NS5
@en
Structural and functional anal ...... ase domain of dengue virus NS5
@nl
P50
P3181
P1476
Structural and functional anal ...... ase domain of dengue virus NS5
@en
P2093
Delphine Benarroch
Marie-Pierre Egloff
P304
P3181
P356
10.1016/J.JMB.2007.07.005
P407
P577
2007-09-21T00:00:00Z