Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors
about
The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma KinaseBenzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallographyDevelopment and strategies of VEGFR-2/KDR inhibitors.Type-II kinase inhibitor docking, screening, and profiling using modified structures of active kinase statesProtein kinase inhibitors: contributions from structure to clinical compounds.Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors.Small-molecule inhibitors binding to protein kinase. Part II: the novel pharmacophore approach of type II and type III inhibition.Development of anti-angiogenic tyrosine kinases inhibitors: molecular structures and binding modes.Benzamide capped peptidomimetics as non-ATP competitive inhibitors of CDK2 using the REPLACE strategy.Synthesis and biological evaluation of novel 4-(2-fluorophenoxy)-2-(1H-tetrazol-1-yl)pyridines bearing semicarbazone moieties as potent antitumor agents.Discovery of novel vascular endothelial growth factor receptor 2 inhibitors: a virtual screening approach.Design and synthesis of 2-iminothiazolidin-4-one moiety-containing compounds as potent antiproliferative agents.Design, synthesis and evaluation of novel rhodanine-containing sorafenib analogs as potential antitumor agents.3D-QSAR study of Chk1 kinase inhibitors based on docking.Inhibition of cell proliferation, vascular endothelial growth factor and tumor growth by albendazole.Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.Automatic α-helix identification in Patterson maps.Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulations.Application of shape-based and pharmacophore-based in silico screens for identification of Type II protein kinase inhibitors.Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
P2860
Q27671787-A543E50F-C443-41D1-AEA5-6E2D8294493BQ27674450-E34D31E7-089C-4F8C-A411-EADC4041A16BQ34436101-E0880FD6-F6ED-4F45-A06F-2AEFE9771FCCQ37160025-83A53695-D84F-4180-AE10-D5970E366977Q37417742-B5238359-E750-481A-A83B-AAF158B5250DQ37441006-377E076D-99E5-4040-811F-05BC4E04EF5CQ38090664-99BFA9C2-C9FB-40DF-8F40-0C4169962B01Q38701634-60682483-A843-424B-94B2-0502CB6BB549Q38764692-29A7D85E-EC53-49CE-ADD9-1E79C40CB4CCQ39082051-F8F4CFB9-25CC-4CDE-BD8D-4BC00BFF630FQ39292974-38D3F169-FF73-4B66-B4FD-3A787B553E79Q39416611-B29B3138-23C6-4437-8972-6ABC90EA0136Q39571492-2331778A-16D2-486B-B690-F13CA8EFFE22Q39647828-69CE8D40-9A82-4353-A50F-29C8BFE05BD8Q39880781-51C1EEEA-5527-4272-AC25-F2869764C996Q41108643-F863F24F-A075-407F-BF16-A9F59A493D12Q51465642-25615E5B-360F-4E0D-A139-EBAF8F41A9C9Q52668906-0D9226B7-71D4-479F-945F-06200060FE4BQ54580789-51F681D9-9795-4CD8-B8C6-F5EDD121D066Q57821196-26BD07A1-9CA1-4E37-8030-ABC75245831A
P2860
Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@ast
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@en
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@nl
type
label
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@ast
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@en
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@nl
prefLabel
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@ast
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@en
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@nl
P2093
P356
P1476
Design, synthesis, and evaluat ...... tor tyrosine kinase inhibitors
@en
P2093
Alexander M Long
Angela Coxon
Anthony Polverino
Daniel Elbaum
Douglas Whittington
Gondi N Kumar
Huilin Zhao
James Bready
Joseph L Kim
Juan Estrada
P304
P356
10.1021/JM070034I
P407
P577
2007-09-06T00:00:00Z