Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding

Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding

Item
http://www.wikidata.org/entity/Q27648653
Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGTHow to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylaseFrom lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clustersHot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzymeReplacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT)Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionQueuosine modification of tRNA: its divergent role in cellular machinery.A medicinal chemist's guide to molecular interactionsStructure and function of noncanonical nucleobases.Molecular recognition in chemical and biological systems.High-affinity inhibitors of tRNA-guanine transglycosylase replacing the function of a structural water cluster.An Immucillin-Based Transition-State-Analogous Inhibitor of tRNA-Guanine Transglycosylase (TGT).
P2860

Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding

Item
http://www.wikidata.org/entity/Q27648653
description
2007 nî lūn-bûn
@nan
2007 թուականին հրատարակուած գիտական յօդուած
@hyw
2007 թվականին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@ast
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@en
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@nl
type
label
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@ast
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@en
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@nl
prefLabel
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@ast
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@en
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Potent inhibitors of tRNA-guan ...... arge-assisted hydrogen bonding
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698