De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinityX-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding AffinityA fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactionsCrystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate bindingFluorine in pharmaceuticals: looking beyond intuitionPotent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bondingSynthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesisInhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysisCation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ionsCrystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGTMolecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitorHow to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylaseSystematic investigation of halogen bonding in protein-ligand interactionsMolecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitorsInhibitors of the herbicidal target IspD: allosteric site bindingHalogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environmentsMolecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural waterFrom lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clustersOptimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin LPseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspDBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseChasing protons: how isothermal titration calorimetry, mutagenesis, and pKa calculations trace the locus of charge in ligand binding to a tRNA-binding enzymeBeyond affinity: enthalpy-entropy factorization unravels complexity of a flat structure-activity relationship for inhibition of a tRNA-modifying enzymeReplacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT)Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activitiesAddressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB MimicOccupying a flat subpocket in a tRNA-modifying enzyme with ordered or disordered side chains: Favorable or unfavorable for binding?Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparumPreparation of Enantiomerically Pure C76 with a General Electrochemical Method for the Removal of Di(alkoxycarbonyl)methano Bridges from Methanofullerenes: The Retro-Bingel ReactionEffects of structural modification on gene transfection and self-assembling properties of amphiphilic dendrimers.Bisubstrate inhibitors of catechol O-methyltransferase (COMT): the crucial role of the ribose structural unit for inhibitor binding affinity.A fluorine scan at the catalytic center of thrombin: C--F, C--OH, and C--OMe bioisosterism and fluorine effects on pKa and log D values.Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p pocket.New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates.Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionBetraying the parasite's redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties.Supramolecular chemistry of dendrimers with functional cores.Interactions with aromatic rings in chemical and biological recognition.Allenes in molecular materials.Launching spiking ligands into a protein-protein interface: a promising strategy to destabilize and break interface formation in a tRNA modifying enzyme.
P50
Q27638639-23906930-77F6-4A88-A3E4-C5952C278E25Q27639887-8830B9A2-CE7D-48B2-BAEF-A69F2AFFD991Q27641429-5F534A5B-C875-48A3-BE82-87D460270383Q27644905-32D6C7D2-3973-45D1-920E-0D5F89DD4951Q27648640-D64E8C2C-E1CA-4836-80F7-6E928624E30BQ27648653-41E25201-EEA4-4118-8643-97BFE479E53FQ27649129-BA20B9A6-5A36-44E0-BBDE-275ADED0BB6AQ27651221-53ABADEA-BE32-44FE-B203-C54ACB93BD48Q27653228-E48FC3BA-BD1A-435A-B65F-55DB3EBA417BQ27653676-351E25ED-F5EC-4A9C-AB3B-919DA068D222Q27658035-BC4157F5-3AC6-426A-B8FF-A68DA0D2F972Q27658079-28DE0F8E-F283-49A9-8A70-2DBBA9B949D4Q27666413-E9CD794F-1F67-4DA1-944E-FEEB9BF8A1D5Q27667660-F9DB47AF-8EF8-4E60-B8C8-8DD56F13DC0AQ27670854-44780CB6-B8E6-4031-8B64-C0C770E3DBA7Q27673373-85DD5D06-486B-47E9-A0B0-1411F1664CC7Q27676143-B9B6C3DD-3F4E-4C54-A856-5453D87DC65CQ27681407-91B44F4C-B033-49B9-A68F-D6F1F41BD7E0Q27684569-A6700F74-28A1-4179-9797-82F973852517Q27688950-79E78E1F-A4BA-4F71-9CFE-EB563C84B0FEQ27690137-5821C854-CBB0-4E97-9A68-B6840F33B9C7Q27690788-E201C156-F9B3-4CC1-9D12-E14D3D746A7EQ27690797-37F7F45C-C024-4FA7-BA07-47055D7470DBQ27696473-6FA1BEA7-328A-4BBF-8119-B6C8643BB322Q27698528-28931AB1-F92F-43E9-AB69-31EA2E46F10FQ27702642-29E29621-3261-4659-86DB-5029739C2F8EQ27726746-EE3E1188-9055-40B3-800D-481478A63FBAQ28487248-BCFDF2E0-0B2C-4E0A-AF7C-0A4FA878D126Q29013621-01ECE223-246B-4E7D-832C-2BBCC1CAEE67Q33234472-923C88AA-09D9-4FBC-868B-0625A79C8192Q33253060-B4C62CDE-3078-4D19-9EB5-FAC8E8B4D82EQ33253065-D40AC238-6C1E-47D0-A3FA-E497654C18BAQ33258421-ABC6A0EC-9B57-4AF8-B0EC-9FD90D89CE8AQ33504614-3CFE60E8-564C-4961-B548-62DF94BDB25EQ33574433-61F6E5D7-E447-4010-A04B-ABC0B3750934Q34007340-EC705FB3-95E5-4715-8F1B-F018B17A9EEBQ34022039-B8B9A52E-EA19-43B3-858D-715E28EE8007Q34184583-CAE5D103-AA8A-42FF-BA47-A0DD15CDA060Q34252320-0E33D005-0663-4058-96CD-A16388FBB72CQ34638284-27025C68-E6CA-4465-A18E-6C0204D76D56
P50
description
Luksemburgi keemik
@et
Luxembourg chemist
@en-ca
Luxembourg chemist
@en-gb
Luxembourgian chemist
@en
Luxemburgs scheikundige
@nl
ceimiceoir Lucsamburgach
@ga
chimist luxemburghez
@ro
chimiste luxembourgeois
@fr
luxemburgischer Chemiker
@de
químic luxemburguès
@ca
name
François Diederich
@ast
François Diederich
@da
François Diederich
@de
François Diederich
@en
François Diederich
@es
François Diederich
@fr
François Diederich
@ga
François Diederich
@lb
François Diederich
@nb
François Diederich
@nl
type
label
François Diederich
@ast
François Diederich
@da
François Diederich
@de
François Diederich
@en
François Diederich
@es
François Diederich
@fr
François Diederich
@ga
François Diederich
@lb
François Diederich
@nb
François Diederich
@nl
prefLabel
François Diederich
@ast
François Diederich
@da
François Diederich
@de
François Diederich
@en
François Diederich
@es
François Diederich
@fr
François Diederich
@ga
François Diederich
@lb
François Diederich
@nb
François Diederich
@nl
P166
P463
P1006
P214
P227
P244
P268
P269
P1006
P1412
P166
P19
P21
P213
0000 0001 1562 2804
P214
P227
P2381
P244
nr92014024