about
Molecular architecture of human polycomb repressive complex 2Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expressionThe interplay of histone modifications - writers that readPolycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.Role of the polycomb protein EED in the propagation of repressive histone marksBinding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1A novel mutation in EED associated with overgrowthModulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesNovel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cellsEZH2: not EZHY (easy) to deal.The central role of EED in the orchestration of polycomb group complexes.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Inner workings and regulatory inputs that control Polycomb repressive complex 2A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.EZH2: biology, disease, and structure-based drug discoveryEZH2: novel therapeutic target for human cancerComputational prediction of associations between long non-coding RNAs and proteins.Pseudomonas syringae effector protein AvrB perturbs Arabidopsis hormone signaling by activating MAP kinase 4.Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer.Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.DDB2 modulates TGF-β signal transduction in human ovarian cancer cells by downregulating NEDD4L.Ezh1 and Ezh2 maintain repressive chromatin through different mechanismsPolycomb and the emerging epigenetics of pancreatic cancer.Structural Chemistry of Human SET Domain Protein Methyltransferases.Mind the methyl: methyllysine binding proteins in epigenetic regulation.The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression.An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer.Structure of the PRC2 complex and application to drug discovery.Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED.Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2.Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.Computational characterization of substrate and product specificities, and functionality of S-adenosylmethionine binding pocket in histone lysine methyltransferases from Arabidopsis, rice and maize.First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.Structure, mechanism, and regulation of polycomb repressive complex 2.Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structural basis of EZH2 recognition by EED
@ast
Structural basis of EZH2 recognition by EED
@en
Structural basis of EZH2 recognition by EED
@nl
type
label
Structural basis of EZH2 recognition by EED
@ast
Structural basis of EZH2 recognition by EED
@en
Structural basis of EZH2 recognition by EED
@nl
prefLabel
Structural basis of EZH2 recognition by EED
@ast
Structural basis of EZH2 recognition by EED
@en
Structural basis of EZH2 recognition by EED
@nl
P2093
P3181
P1433
P1476
Structural basis of EZH2 recognition by EED
@en
P2093
P304
P3181
P356
10.1016/J.STR.2007.08.007
P577
2007-10-01T00:00:00Z