An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
about
Exploiting Epigenetic Alterations in Prostate Cancer.Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens.Inhibitors of Protein Methyltransferases and Demethylases.EZH2 inhibitors: a patent review (2014-2016).Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.Recent progress in developing selective inhibitors of protein methyltransferases.Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation.Long non-coding RNA SNHG15 inhibits P15 and KLF2 expression to promote pancreatic cancer proliferation through EZH2-mediated H3K27me3.WD40 repeat domain proteins: a novel target class?Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease.Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways.Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin.Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.Mechanisms of resistance to EZH2 inhibitors in diffuse large B-cell lymphomas.Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes?Recent Advances in Prostate Cancer Treatment and Drug Discovery.
P2860
Q33755160-741FA2DC-FBEB-4D67-9083-A6163AF831BDQ38156730-2DCB9622-CBDD-4501-9EB9-EA71C46F4372Q38740496-5090106F-2EF4-4B8D-835E-C0906E6F1F31Q38844652-A0C18619-2DEB-49D1-B98E-B17261FBEC9DQ39261435-2D59E9D5-EA8B-40CD-9997-EAFA15B6D782Q39405190-F900DC94-5A69-4431-B099-F52D6201D41DQ39423291-9156B465-DCB4-431C-8476-FF1364383CE5Q47135296-79D38FAC-8277-49AA-8F69-5154DF2C6B85Q47291150-51DDEB33-CE00-4DC4-8C77-E0613CDCEDE2Q47308611-498BB22D-7A9F-4449-819E-FF0C546D6DB9Q51733364-EE3A76C9-349D-49FB-89F7-5940EF52ED41Q52313298-636BF090-9035-4355-9E0C-3865B4F1E0E0Q52313301-C6DC4A78-DA53-47D6-B64A-4FB98AA8D665Q52639446-6700FCED-01A2-4953-B373-77A00E904FB9Q52715499-0575E115-9341-4863-97D8-FF1501C55592Q54111821-EE066D57-B92B-4024-ADDE-7234AFED234C
P2860
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
2017年论文
@zh
2017年论文
@zh-cn
name
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
@en
type
label
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
@en
prefLabel
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
@en
P2093
P2860
P356
P1476
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
@en
P2093
Andreas Lingel
Chao Zhang
Chenhui Zeng
Counde Oyang
Douglas Fang
Fangjun Luo
Hailong Zhang
HoMan Chan
P2860
P2888
P304
P356
10.1038/NCHEMBIO.2304
P50
P577
2017-01-30T00:00:00Z