Discovery of a novel warhead against beta-secretase through fragment-based lead generation
about
Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsStructural characterization and inhibition of the Plasmodium Atg8–Atg3 interactionDiscovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer DiseaseExperimental and computational active site mapping as a starting point to fragment-based lead discoveryMissing Fragments: Detecting Cooperative Binding in Fragment-Based Drug DesignVirtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitorsStructure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistryTracing binding modes in hit-to-lead optimization: chameleon-like poses of aspartic protease inhibitorsFragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial ChemistryCreating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug designIntegrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Virtual fragment screening: exploration of MM-PBSA re-scoring.Therapeutic approaches to preventing cell death in Huntington diseaseFragment screening by surface plasmon resonance.Lessons from Hot Spot Analysis for Fragment-Based Drug Discovery.Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?Application of optical biosensors in small-molecule screening activities.Recent progress in the drug discovery of non-peptidic BACE1 inhibitors.Advances in the identification of β-secretase inhibitors.Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.Creation of Novel Cores for β-Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy.Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.Systematic screening of viral entry inhibitors using surface plasmon resonance.Synthesis of amino heterocycle aspartyl protease inhibitors.Fragment-based similarity searching with infinite color space.Modulating Antibody Structure and Function through Directed Mutations and Chemical Rescue.Developing consensus 3D-QSAR and pharmacophore models for several beta-secretase, farnesyl transferase and histone deacetylase inhibitors.
P2860
Q26740189-3BF5DDC7-9798-4D04-BE66-1F55D8871D46Q27673186-0D98A37B-2D9D-488C-966F-C14862128573Q27674362-B8F65CC0-36D3-43DB-BAC4-152954B350A0Q27676521-EACCD92D-21FC-4F73-8104-D1F9202DDB66Q27684142-0B9E96B8-3B04-43DA-9726-E029EC145DFBQ27684634-2657C6A8-465D-4497-8F8D-091E4055B135Q27689107-3ED06AAF-2D5A-4965-A45D-664A191D6D36Q27697678-FF2DE62A-650D-420E-92C9-DE84D21D9935Q27718399-D670CC3E-0B8E-440B-9779-BCD6C17E5E16Q28543133-BFD7259F-7723-4C9C-B71F-D1B1D490D2C6Q33852386-34CA2C46-F17A-4839-8E3A-EDE88F920CE6Q33862796-4746BCB7-B96F-4DA6-A65E-CFD4217CF7D9Q34007475-99362CC1-62EA-4194-A42A-EA7061162490Q34368348-3267E8E5-6972-43EE-A209-D94FF334E5B9Q34411338-CC192FEE-A958-47CB-BDF9-2B1674CD00C0Q35181877-5DAD9CF0-E43B-4EAF-9520-13B432982EA8Q36269125-A4489E8A-7628-4864-931C-18EEB7F159A6Q37198579-BBF899AB-BC07-4C37-B661-16E60351B3B9Q38016148-866E67CF-4A1E-4D3C-B902-DB79B22FF930Q38088811-8889F188-349F-4754-97BC-F00843055E26Q38097074-CC144F18-C20E-4AAB-9BC1-1A0CD8691085Q38972869-524FFA46-2C8E-4D01-8E65-B499D35CCB38Q39786441-F4E98D5B-19CB-463D-9202-A1788A7FC15FQ41672360-FBF3E7CC-24BF-43EF-B4A3-54F7AF104763Q44105945-DA130103-B2BB-44C5-9CEF-D37C9F3E377AQ50856369-6227DFAB-D91A-4580-A950-626469B217C1Q50891672-ED2E3D23-7008-46D9-8062-C60C5E5C8186Q52690535-4D91A9DE-230F-4497-A1FB-BC3F41561940Q53925655-76A7500B-DFCE-4578-B5F3-C5EC73946B36
P2860
Discovery of a novel warhead against beta-secretase through fragment-based lead generation
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Discovery of a novel warhead a ...... fragment-based lead generation
@ast
Discovery of a novel warhead a ...... fragment-based lead generation
@en
Discovery of a novel warhead a ...... fragment-based lead generation
@nl
type
label
Discovery of a novel warhead a ...... fragment-based lead generation
@ast
Discovery of a novel warhead a ...... fragment-based lead generation
@en
Discovery of a novel warhead a ...... fragment-based lead generation
@nl
prefLabel
Discovery of a novel warhead a ...... fragment-based lead generation
@ast
Discovery of a novel warhead a ...... fragment-based lead generation
@en
Discovery of a novel warhead a ...... fragment-based lead generation
@nl
P2093
P3181
P356
P1476
Discovery of a novel warhead a ...... fragment-based lead generation
@en
P2093
Jeffrey S Albert
Johanna Deinum
Lise-Lotte Olsson
Philip D Edwards
Rutger H A Folmer
Stefan Geschwindner
Tonny de Beer
P304
P3181
P356
10.1021/JM070825K
P407
P577
2007-11-29T00:00:00Z