Experimental and computational active site mapping as a starting point to fragment-based lead discovery

Experimental and computational active site mapping as a starting point to fragment-based lead discovery

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http://www.wikidata.org/entity/Q27676521
Dissecting the hydrophobic effect on the molecular level: the role of water, enthalpy, and entropy in ligand binding to thermolysinPseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspDMethyl, ethyl, propyl, butyl: futile but not for water, as the correlation of structure and thermodynamic signature shows in a congeneric series of thermolysin inhibitorsProtein crystallography and fragment-based drug design.High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists.Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery.Insight into the structural similarity between HIV protease and secreted aspartic protease-2 and binding mode analysis of HIV-Candida albicans inhibitors.On the origins of drug polypharmacologyGas-sensitive biological crystals processed in pressurized oxygen and krypton atmospheres: deciphering gas channels in proteins using a novel `soak-and-freeze' methodology
P2860

Experimental and computational active site mapping as a starting point to fragment-based lead discovery

Item
http://www.wikidata.org/entity/Q27676521
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Experimental and computational ...... fragment-based lead discovery
@ast
Experimental and computational ...... fragment-based lead discovery
@en
Experimental and computational ...... fragment-based lead discovery
@nl
type
label
Experimental and computational ...... fragment-based lead discovery
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Experimental and computational ...... fragment-based lead discovery
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Experimental and computational ...... fragment-based lead discovery
@nl
prefLabel
Experimental and computational ...... fragment-based lead discovery
@ast
Experimental and computational ...... fragment-based lead discovery
@en
Experimental and computational ...... fragment-based lead discovery
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
Experimental and computational ...... fragment-based lead discovery
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698