Structural characterization of a mutated, ADCC-enhanced human Fc fragment
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A perspective on the structure and receptor binding properties of immunoglobulin G FcStructural characterization of a human Fc fragment engineered for lack of effector functionsChemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan BiosynthesisEngineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of BiotherapeuticsImmunoglobulin G1 Fc Domain Motions: Implications for Fc EngineeringStructural Characterization of Anti-Inflammatory Immunoglobulin G Fc ProteinsDynamics of inter-heavy chain interactions in human immunoglobulin G (IgG) subclasses studied by kinetic Fab arm exchange.Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling.Protein post-translational modifications: In silico prediction tools and molecular modeling.Crystallization and preliminary X-ray diffraction analysis of the complex of a human anti-ephrin type-A receptor 2 antibody fragment and its cognate antigen.Explaining the non-newtonian character of aggregating monoclonal antibody solutions using small-angle neutron scattering.Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals.Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.Engineering upper hinge improves stability and effector function of a human IgG1.Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding.Revisiting the role of glycosylation in the structure of human IgG Fc.Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa.Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled SyringesDevelopment of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells.Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptorsAglycosylated antibodies and the methods of making and using them: WO2008030564.Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant.Function and 3D structure of the N-glycans on glycoproteins.Structural analysis of Fc/FcγR complexes: a blueprint for antibody design.Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs.Engineered protease-resistant antibodies with selectable cell-killing functions.Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability.Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties.Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon alpha-2A.Antitumor Efficacy of Anti-GD2 IgG1 Is Enhanced by Fc Glyco-EngineeringInsights from Fc receptor biology: a route to improved antibody reagents.Both protein adsorption and aggregation contribute to shear yielding and viscosity increase in protein solutions.IgG Fc engineering to modulate antibody effector functions.Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinityActivating and inhibitory Fcγ receptors in immunotherapy: being the actor or being the target
P2860
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P2860
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@ast
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@en
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@nl
type
label
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@ast
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@en
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@nl
prefLabel
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@ast
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@en
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@nl
P2093
P1433
P1476
Structural characterization of a mutated, ADCC-enhanced human Fc fragment
@en
P2093
Melissa M Damschroder
William F Dall'Acqua
William Leach
P304
P356
10.1016/J.MOLIMM.2007.10.042
P577
2008-04-01T00:00:00Z