Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase
about
Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197Ten things you should know about protein kinases: IUPHAR Review 14Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-MetEnergetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations.Cancer driver mutations in protein kinase genesDiscovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay.Small molecule c-Met kinase inhibitors: a review of recent patents.A rapid and sensitive LC-MS/MS method for evaluation of the absolute oral bioavailability of a novel c-Met tyrosine kinase inhibitor QBH-196 in rats.Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screeningTea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.Design and Synthesis of Novel 4-Phenoxyquinolines Bearing 3-Hydrosulfonylacrylamido or 1H-Imidazole-4-carboxamido Scaffolds as c-Met Kinase Inhibitors.Novel EGFR (T790M)-cMET dual inhibitors: putative therapeutic agents for non-small-cell lung cancer.Design, Synthesis, and Biological Evaluation of 4-Phenoxyquinoline Derivatives Containing Benzo[d]thiazole-2-yl Urea as c-Met Kinase Inhibitors.Synthesis and biological evaluation of 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazone scaffolds as selective c-Met inhibitors.Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810.Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer.Synthesis and antitumor activity of novel 4-(2-fluorophenoxy)quinoline derivatives bearing the 4-oxo-1,4-dihydroquinoline-3-carboxamide moiety.Insight into the key features for ligand binding in Y1230 mutated c-Met kinase domain by molecular dynamics simulations.Design Some New Type-I c-met Inhibitors Based on Molecular Docking and Topomer CoMFA Research.O-linked triazolotriazines: potent and selective c-Met inhibitors.Pharmacophore modeling and virtual screening studies to identify new c-Met inhibitors.Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors.Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors
P2860
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P2860
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Discovery and optimization of ...... inhibitors of the c-Met kinase
@ast
Discovery and optimization of ...... inhibitors of the c-Met kinase
@en
Discovery and optimization of ...... inhibitors of the c-Met kinase
@nl
type
label
Discovery and optimization of ...... inhibitors of the c-Met kinase
@ast
Discovery and optimization of ...... inhibitors of the c-Met kinase
@en
Discovery and optimization of ...... inhibitors of the c-Met kinase
@nl
prefLabel
Discovery and optimization of ...... inhibitors of the c-Met kinase
@ast
Discovery and optimization of ...... inhibitors of the c-Met kinase
@en
Discovery and optimization of ...... inhibitors of the c-Met kinase
@nl
P2093
P356
P1476
Discovery and optimization of ...... inhibitors of the c-Met kinase
@en
P2093
Aaron Siegmund
Alessandro A Boezio
Alexander M Long
Anne O'Connor
April Chen
Brian K Albrecht
Cary Fridrich
Christiane Bode
David Bauer
Deborah Choquette
P304
P356
10.1021/JM800043G
P407
P577
2008-05-22T00:00:00Z