Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
about
The IkappaB kinase complex: master regulator of NF-kappaB signalingNEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domainStructure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactionsNF-κB regulation: lessons from structuresSuper-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmentiCrystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitinCrystal structure of inhibitor of κB kinase βCrystal Structure of a Human I B Kinase Asymmetric DimerIdentification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assaysProbing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR SpectroscopyThe IKK complex, a central regulator of NF-kappaB activationInhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.Cell penetrating peptide inhibitors of nuclear factor-kappa B.Protein engineering of the N-terminus of NEMO: structure stabilization and rescue of IKKβ binding.A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylationThe IκB kinase complex in NF-κB regulation and beyond.Binding mode analysis of zerumbone to key signal proteins in the tumor necrosis factor pathway.NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy.Nuclear initiated NF-κB signaling: NEMO and ATM take center stage.IKK biology.Evidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO.Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin InteractionNovel Phosphorylations of IKKγ/NEMO.The pivotal role of TBK1 in inflammatory responses mediated by macrophagesRelationship between hot spot residues and ligand binding hot spots in protein-protein interfaces.Molecular basis of NF-κB signalingStructural basis of signal transduction in the TNF receptor superfamilyNEMO oligomerization and its ubiquitin-binding properties.Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.A structural guide to proteins of the NF-kappaB signaling module.NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.IκB kinase γ/nuclear factor-κB-essential modulator (IKKγ/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKKβ in response to transforming growth factor (TGF)-β1Linear polyubiquitination: a new regulator of NF-kappaB activation.Structural studies of NF-κB signaling.Inhibitory kappa B Kinases as targets for pharmacological regulation.Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamilyHuman kinome drug discovery and the emerging importance of atypical allosteric inhibitors.COMMD7 as a novel NEMO interacting protein involved in the termination of NF-κB signaling.Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).Identification of a new NEMO/TRAF6 interface affected in incontinentia pigmenti pathology.
P2860
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P2860
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@ast
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@en
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@nl
type
label
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@ast
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@en
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@nl
prefLabel
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@ast
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@en
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@nl
P2093
P3181
P1433
P1476
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
@en
P2093
Alexey Lugovskoy
Anne Cheung
Hernan Cuervo
Kevin Guckian
Ling Ling Chen
Sarah Bixler
Scott Bowes
Steven Berkowitz
Timothy Zheng
P304
P3181
P356
10.1016/J.STR.2008.02.012
P577
2008-05-01T00:00:00Z