Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance - Wikidata - wikimedia - TriplyDB

Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

http://www.wikidata.org/entity/Q27652457

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O-GlcNAcylation and Metabolic Reprograming in Cancer GlcNAcstatins are nanomolar inhibitors of human O -GlcNAcase inducing cellular hyper- O -GlcNAcylation Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ Screening-based discovery of drug-likeO-GlcNAcase inhibitor scaffolds Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress Quantitative secretome and glycome of primary human adipocytes during insulin resistance.O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells.O-GlcNAc signaling: a metabolic link between diabetes and cancer?Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling.Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner.OGA inhibition by GlcNAc-selenazoline Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway Hexosamine biosynthesis is a possible mechanism underlying hypoxia's effects on lipid metabolism in human adipocytes Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance.Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease.The roles of O-linked β-N-acetylglucosamine in cardiovascular physiology and disease.Identification of O-linked N-acetylglucosamine (O-GlcNAc)-modified osteoblast proteins by electron transfer dissociation tandem mass spectrometry reveals proteins critical for bone formation.Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis.O-linked N-acetylglucosamine cycling regulates mitotic spindle organization.Cracking the O-GlcNAc code in metabolism.Defining the structural origin of the substrate sequence independence of O-GlcNAcase using a combination of molecular docking and dynamics simulation.O-GlcNAc cycling: implications for neurodegenerative disorders.O-GlcNAcomics--Revealing roles of O-GlcNAcylation in disease mechanisms and development of potential diagnostics.The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways.Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes.O-GlcNAc and the cardiovascular system.Glycosidase inhibition: assessing mimicry of the transition state.Protein O-GlcNAcylation in diabetes and diabetic complications.Chemical tools to probe cellular O-GlcNAc signalling.PUGNAc induces protein ubiquitination in C2C12 myotube cells.

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P2860

Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

http://www.wikidata.org/entity/Q27652457

description

2008 nî lūn-bûn

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2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Elevation of Global O-GlcNAc L ...... Not Induce Insulin Resistance

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Abigail K Bubb

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Carlos Martinez-Fleites

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Matthew S Macauley

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P2860

Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation

Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

Updating the sequence-based classification of glycosyl hydrolases

Hexosamines, insulin resistance, and the complications of diabetes: current status.

Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB

Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase

Structure of the integrin alpha2beta1-binding collagen peptide

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

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34687-95

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10.1074/JBC.M804525200

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50

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283

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David J Vocadlo

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2008-12-12T00:00:00Z

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