Structural insights into the inhibited states of the Mer receptor tyrosine kinase
about
Discovery of Mer kinase inhibitors by virtual screening using Structural Protein-Ligand Interaction Fingerprints.Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic LeukemiaUNC1062, a new and potent Mer inhibitor.Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays.Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors.Structure-Based Virtual Screening of Commercially Available Compound Libraries.αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.TAM receptors in leukemia: expression, signaling, and therapeutic implications.Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitorsBiology of the TAM receptors.UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivoMERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL.Structural elucidation of the DFG-Asp in and DFG-Asp out states of TAM kinases and insight into the selectivity of their inhibitors.Identity-by-descent-guided mutation analysis and exome sequencing in consanguineous families reveals unusual clinical and molecular findings in retinal dystrophy.The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening.
P2860
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P2860
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@ast
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@en
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@nl
type
label
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@ast
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@en
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@nl
prefLabel
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@ast
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@en
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@nl
P2093
P2860
P50
P1476
Structural insights into the inhibited states of the Mer receptor tyrosine kinase
@en
P2093
Benjamin E Turk
Christine Butler-Cole
Debra A Thompson
John R Walker
Patrick Finerty
Sirlester A Parker
Xudong Huang
P2860
P356
10.1016/J.JSB.2008.10.003
P577
2009-02-01T00:00:00Z