Structural insights into the inhibited states of the Mer receptor tyrosine kinase - Wikidata - wikimedia - TriplyDB

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

http://www.wikidata.org/entity/Q27652978

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Discovery of Mer kinase inhibitors by virtual screening using Structural Protein-Ligand Interaction Fingerprints.Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia UNC1062, a new and potent Mer inhibitor.Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays.Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors.Structure-Based Virtual Screening of Commercially Available Compound Libraries.αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.TAM receptors in leukemia: expression, signaling, and therapeutic implications.Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors Biology of the TAM receptors.UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL.Structural elucidation of the DFG-Asp in and DFG-Asp out states of TAM kinases and insight into the selectivity of their inhibitors.Identity-by-descent-guided mutation analysis and exome sequencing in consanguineous families reveals unusual clinical and molecular findings in retinal dystrophy.The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening.

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P2860

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

http://www.wikidata.org/entity/Q27652978

description

2009 nî lūn-bûn

@nan

2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@ast

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@en

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@nl

type

label

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@ast

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@en

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@nl

prefLabel

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@ast

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@en

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@nl

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J.JSB.2008.10.003

P1433

Journal of Structural Biology

P1476

Structural insights into the inhibited states of the Mer receptor tyrosine kinase

@en

P2093

Benjamin E Turk

http://www.w3.org/2001/XMLSchema#string

Christine Butler-Cole

http://www.w3.org/2001/XMLSchema#string

Debra A Thompson

http://www.w3.org/2001/XMLSchema#string

John R Walker

http://www.w3.org/2001/XMLSchema#string

Patrick Finerty

http://www.w3.org/2001/XMLSchema#string

Sirlester A Parker

http://www.w3.org/2001/XMLSchema#string

Xudong Huang

http://www.w3.org/2001/XMLSchema#string

P2860

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

Functional proteomics mapping of a human signaling pathway

Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.

Improved methods for building protein models in electron density maps and the location of errors in these models

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3)

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

Maximum-likelihood density modification

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88-96

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scholarly article

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10.1016/J.JSB.2008.10.003

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2

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165

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Sirano Dhe-Paganon

Matthieu Schapira

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2009-02-01T00:00:00Z

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P5875

23492500

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19028587

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structural biology

P932

2686088

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