Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.
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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionInhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemiaThe C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1Structural insights into the inhibited states of the Mer receptor tyrosine kinaseGas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responsesThe kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylationA single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.Invasive glioblastoma cells acquire stemness and increased Akt activation.Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemiaRegulation of phagocytosis by TAM receptors and their ligands.MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.Mertk deficiency affects macrophage directional migration via disruption of cytoskeletal organization.Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.Gene expression profiling in childhood acute leukemia: progress and perspectives.MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib.Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors.Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cellsThe receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophages.TAM receptors in leukemia: expression, signaling, and therapeutic implications.Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokersMer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia.Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase.Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress.Biology of the TAM receptors.The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages.A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells.A genomic screen identifies TYRO3 as a MITF regulator in melanoma.MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL.PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase.Axl and Mer Receptor Tyrosine Kinases: Distinct and Nonoverlapping Roles in Inflammation and Cancer?Gas6 anti-apoptotic signaling requires NF-kappa B activation.An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action.Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activatLymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase.MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat.The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.
P2860
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P2860
Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Biological effects of c-Mer re ...... or and activation of NF-kappaB
@nl
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@ast
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@en
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@en-gb
type
label
Biological effects of c-Mer re ...... or and activation of NF-kappaB
@nl
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@ast
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@en
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@en-gb
prefLabel
Biological effects of c-Mer re ...... or and activation of NF-kappaB
@nl
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@ast
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@en
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@en-gb
P2093
P2860
P3181
P356
P1476
Biological effects of c-Mer re ...... r and activation of NF-kappaB.
@en
P2093
H Hanafusa
K H Kirsch
M M Georgescu
T Shishido
P2860
P304
P3181
P356
10.1128/MCB.19.2.1171
P407
P577
1999-02-01T00:00:00Z