Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility
about
Following evolutionary paths to protein-protein interactions with high affinity and selectivityMechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid ReceptorStructure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-LactamaseTracing Primordial Protein Evolution through Structurally Guided Stepwise Segment ElongationA designed supramolecular protein assembly with in vivo enzymatic activityOvercoming differences: The catalytic mechanism of metallo-β-lactamasesStabilization of a metabolic enzyme by library selection in Thermus thermophilus.Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Experimental evolution of adenylate kinase reveals contrasting strategies toward protein thermostability.First-step mutations for adaptation at elevated temperature increase capsid stability in a virus.Computational analysis of pathogen-borne metallo β-lactamases reveals discriminating structural features between B1 types.Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro EvolutionQM/MM studies of monozinc β-lactamase CphA suggest that the crystal structure of an enzyme-intermediate complex represents a minor pathway.Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the hydrolysis reaction.Exploring sequence requirements for C₃/C₄ carboxylate recognition in the Pseudomonas aeruginosa cephalosporinase: Insights into plasticity of the AmpC β-lactamase.Molecular evolution of threonine dehydratase in bacteria.Functional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli.Host-specific enzyme-substrate interactions in SPM-1 metallo-β-lactamase are modulated by second sphere residues.Protein variants form a system of networks: microdiversity of IMP metallo-beta-lactamases.Quantitative Description of a Protein Fitness Landscape Based on Molecular Features.Antibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases worldX-ray absorption spectroscopy of metal site speciation in the metallo-β-lactamase BcII from Bacillus cereus.Probing the role of Met221 in the unusual metallo-β-lactamase GOB-18.Common mechanistic features among metallo-beta-lactamases: a computational study of Aeromonas hydrophila CphA enzyme.Metal-Directed Design of Supramolecular Protein Assemblies.The role of ACT-like subdomain in bacterial threonine dehydratases.Insights into an evolutionary strategy leading to antibiotic resistance.Metallo-β-lactamase structure and function.Dynamics and constraints of enzyme evolution.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Catalytic role of the metal ion in the metallo-beta-lactamase GOB.The Role of Active Site Flexible Loops in Catalysis and of Zinc in Conformational Stability of Bacillus cereus 569/H/9 β-Lactamase.A potential substrate binding conformation of β-lactams and insight into the broad spectrum of NDM-1 activityUnderstanding the broad substrate repertoire of nitroreductase based on its kinetic mechanism.How mutational epistasis impairs predictability in protein evolution and designDrug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution.Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase.The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.Network Analysis of Protein Adaptation: modeling the functional impact of multiple mutations.
P2860
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P2860
Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Adaptive protein evolution gra ...... ving catalysis and flexibility
@ast
Adaptive protein evolution gra ...... ving catalysis and flexibility
@en
Adaptive protein evolution gra ...... ving catalysis and flexibility
@nl
type
label
Adaptive protein evolution gra ...... ving catalysis and flexibility
@ast
Adaptive protein evolution gra ...... ving catalysis and flexibility
@en
Adaptive protein evolution gra ...... ving catalysis and flexibility
@nl
prefLabel
Adaptive protein evolution gra ...... ving catalysis and flexibility
@ast
Adaptive protein evolution gra ...... ving catalysis and flexibility
@en
Adaptive protein evolution gra ...... ving catalysis and flexibility
@nl
P2093
P2860
P356
P1476
Adaptive protein evolution gra ...... ving catalysis and flexibility
@en
P2093
Alejandro J Vila
Brian J Sutton
Fabio Simona
Pablo E Tomatis
Paolo Carloni
Stella M Fabiane
P2860
P304
P356
10.1073/PNAS.0807989106
P407
P577
2008-12-30T00:00:00Z