Predicting the emergence of antibiotic resistance by directed evolution and structural analysis
about
Quantifying the adaptive potential of an antibiotic resistance enzymeMechanism of the Class I KDPG aldolaseThe genetic code constrains yet facilitates Darwinian evolutionThree decades of beta-lactamase inhibitorsExtended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamasesRAISE: a simple and novel method of generating random insertion and deletion mutationsAcyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillinCharacterization and crystal structure of Escherichia coli KDPGal aldolaseGenetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-LactamaseAdaptive protein evolution grants organismal fitness by improving catalysis and flexibilityStructure of the extended-spectrum β-lactamase TEM-72 inhibited by citrateEvolution to carbapenem-hydrolyzing activity in noncarbapenemase class D -lactamase OXA-10 by rational protein designDirected evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiencyStructural insights into the broadened substrate profile of the extended-spectrum β-lactamase OXY-1-1 from Klebsiella oxytocaEvolution of mutation rates in bacteriaFlexibility Correlation between Active Site Regions Is Conserved across Four AmpC β-Lactamase EnzymesEnvironmental changes bridge evolutionary valleysEvolutionary trajectories of beta-lactamase CTX-M-1 cluster enzymes: predicting antibiotic resistanceNetwork models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectoriesDissecting protein structure and function using directed evolution.Why the extended-spectrum beta-lactamases SHV-2 and SHV-5 are "hypersusceptible" to mechanism-based inhibitorsFisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype spaceMimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations.Directed evolution: an approach to engineer enzymes.Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.Mistranslation can enhance fitness through purging of deleterious mutations.Enzymatic analysis of the effect of naturally occurring Leu138Pro mutation identified in SHV β-lactamase on hydrolysis of penicillin and ampicillin.Initial mutations direct alternative pathways of protein evolutionUnexpected enzyme TEM-126: role of mutation Asp179GluPredicting evolution by in vitro evolution requires determining evolutionary pathways.Mutator bacteria as a risk factor in treatment of infectious diseasesCharacterisation of blaTEM genes and types of β-lactamase plasmids in Neisseria gonorrhoeae - the prevalent and conserved blaTEM-135 has not recently evolved and existed in the Toronto plasmid from the origin.Amino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins.Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases.Combining computational and experimental screening for rapid optimization of protein propertiesEvolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro EvolutionDeep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution.A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutationsMultiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases.
P2860
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P2860
Predicting the emergence of antibiotic resistance by directed evolution and structural analysis
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Predicting the emergence of an ...... lution and structural analysis
@ast
Predicting the emergence of an ...... lution and structural analysis
@en
Predicting the emergence of an ...... lution and structural analysis
@nl
type
label
Predicting the emergence of an ...... lution and structural analysis
@ast
Predicting the emergence of an ...... lution and structural analysis
@en
Predicting the emergence of an ...... lution and structural analysis
@nl
prefLabel
Predicting the emergence of an ...... lution and structural analysis
@ast
Predicting the emergence of an ...... lution and structural analysis
@en
Predicting the emergence of an ...... lution and structural analysis
@nl
P2093
P356
P1476
Predicting the emergence of an ...... lution and structural analysis
@en
P2093
P304
P356
10.1038/84981
P577
2001-03-01T00:00:00Z