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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

http://www.wikidata.org/entity/Q27654656

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Targeting translation initiation in breast cancer Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortui The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors Phase 2 study of subcutaneous omacetaxine mepesuccinate for chronic-phase chronic myeloid leukemia patients resistant to or intolerant of tyrosine kinase inhibitors.Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines Investigation into omacetaxine solution stability for in vitro study.Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation.Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain.The roles of RNA in the synthesis of protein.Neutrons, magnets, and photons: a career in structural biology.The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.Emerging therapeutics targeting mRNA translation Pateamine A-sensitive ribosome profiling reveals the scope of translation in mouse embryonic stem cells High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma Recent Advances in the Development of Antineoplastic Agents Derived from Natural Products Therapeutic interventions to disrupt the protein synthetic machinery in melanoma Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.Homoharringtonine binds to and increases myosin-9 in myeloid leukaemia Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors Inhibitory effect of magnetic Fe3O4 nanoparticles coloaded with homoharringtonine on human leukemia cells in vivo and in vitro.Homoharringtonine and omacetaxine for myeloid hematological malignancies.On the specificity of antibiotics targeting the large ribosomal subunit.Are pleuromutilin antibiotics finally fit for human use?Elements of ribosomal drug resistance and specificity.Omacetaxine mepesuccinate (synribo) - newly launched in chronic myeloid leukemia.Omacetaxine mepesuccinate in the treatment of intractable chronic myeloid leukemia.Fungal natural products in research and development.Brusatol overcomes chemoresistance through inhibition of protein translation.A safety evaluation of omacetaxine mepesuccinate for the treatment of chronic myeloid leukemia.Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.Crystal structure of eukaryotic ribosome and its complexes with inhibitors.

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

http://www.wikidata.org/entity/Q27654656

description

2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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J.JMB.2009.04.005

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Journal of Molecular Biology

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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P2093

Gregor Blaha

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Güliz Gürel

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Peter B Moore

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Thomas A Steitz

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P2860

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

The structural basis of ribosome activity in peptide bond synthesis

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

The structures of four macrolide antibiotics bound to the large ribosomal subunit

Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit

The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole

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10.1016/J.JMB.2009.04.005

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1

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389

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222231556

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19362093

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2682339

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