Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors
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Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α KinaseStructure-kinetic relationship study of CDK8/CycC specific compoundsIdentification of type-II inhibitors using kinase structuresX-ray structure of p38α bound to TAK-715: comparison with three classic inhibitorsDual kinase-bromodomain inhibitors for rationally designed polypharmacologyA Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine KinasesDiscovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)A comprehensive survey of small-molecule binding pockets in proteinsDiverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modificationAffinity reagents that target a specific inactive form of protein kinases.Virtual target screening: validation using kinase inhibitors.Fluorescent biosensors for high throughput screening of protein kinase inhibitors.Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry.Insights from free-energy calculations: protein conformational equilibrium, driving forces, and ligand-binding modesOptimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer modelAccurate calculation of mutational effects on the thermodynamics of inhibitor binding to p38α MAP kinase: a combined computational and experimental studyDetection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR SpectroscopyFluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein KinasesMolecular mechanisms of drug resistance in tyrosine kinases cAbl and cKit.Human kinome drug discovery and the emerging importance of atypical allosteric inhibitors.Protein organic chemistry and applications for labeling and engineering in live-cell systems.Harnessing allostery: a novel approach to drug discovery.A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.Anti-angiogenic Therapy for Retinal Disease.Presence and utility of intrinsically disordered regions in kinases.Characterization of interactions and pharmacophore development for DFG-out inhibitors to RET tyrosine kinase.The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.Scaffold mining of kinase hinge binders in crystal structure database.A Bioorganometallic Approach to Study Histidine Kinase Autophosphorylations.Role of Molecular Interactions and Protein Rearrangement in the Dissociation Kinetics of p38α MAP Kinase Type-I/II/III Inhibitors.Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors.Application of shape-based and pharmacophore-based in silico screens for identification of Type II protein kinase inhibitors.Cation-π interactions in protein-ligand binding: theory and data-mining reveal different roles for lysine and arginine.Biophysical investigation and conformational analysis of p38α kinase inhibitor doramapimod and its analogues
P2860
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P2860
Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@ast
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@en
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@nl
type
label
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@ast
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@en
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@nl
prefLabel
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@ast
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@en
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@nl
P2093
P356
P1476
Development of a fluorescent-t ...... f allosteric kinase inhibitors
@en
P2093
Christian Grütter
Jeffrey R Simard
Matthias Rabiller
Matthäus Getlik
Sabine Wulfert
Vijaykumar Pawar
P304
13286-13296
P356
10.1021/JA902010P
P407
P50
P577
2009-09-01T00:00:00Z