Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl
about
Solution Structure of IseA, an Inhibitor Protein of dl-Endopeptidases from Bacillus subtilis , Reveals a Novel Fold with a Characteristic Inhibitory LoopThe structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein fromClostridium difficileCharacterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole.Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii.Toxoplasma gondii ingests and digests host cytosolic proteins.Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella.Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis.Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondiiType II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection.Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.Lessons from high-throughput protein crystallization screening: 10 years of practical experience.Cathepsin proteases in Toxoplasma gondii.Screening for small molecule inhibitors of Toxoplasma gondii.Novel insights into the composition and function of the Toxoplasma IMC sutures.Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection.Toxoplasma gondii Vps11, a subunit of HOPS and CORVET tethering complexes, is essential for the biogenesis of secretory organelles.Identification and characterization of a cathepsin-L-like peptidase in Eimeria tenella.The parasite Toxoplasma sequesters diverse Rab host vesicles within an intravacuolar network.Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis.Cysteine proteases in protozoan parasites
P2860
Q27674698-55A6634E-EE98-4C8F-9C12-6EBFC528C3F4Q27684602-AE5910AA-111F-4F24-A5BD-A23B79A257A1Q30495595-008324B6-7A0E-4FC1-8250-CFBE8C3C929DQ34016345-520AC34B-071C-4C96-B096-E270ED3135A2Q34165483-0AA36596-2F6D-4968-BEAB-874C3323B90DQ34211633-F3340156-E056-4227-AA49-82BABE106335Q34709118-6B49404C-AE9F-4D2C-8AFD-5A5B350F7638Q35168572-41D9400C-3283-447B-B2CA-1CA7A054F011Q35271230-DB4725EF-8635-4720-B497-8B71E539242AQ35941319-69313D66-A8F3-4496-9788-7570D327AE17Q36579600-59F72E45-5ADC-4D4F-88E6-0288277A2C34Q36798187-D016D038-601C-42E8-BDA3-F4A339892C20Q37635978-0B7616E1-F576-47C2-9580-1CC2FCD23597Q38045464-C0EA41D5-1E99-45FF-86D6-C0F791724FE0Q38410216-FA77EE67-A367-4F6C-B052-EAEC6702CD0BQ40167303-15219939-F5CD-49BB-8D97-15842B1C0060Q41510612-A805640F-1DF7-47EE-A8AE-011F788E8B44Q41728795-89693D6E-B32A-48EC-A76C-6013DBE63A1BQ47603479-BF33850E-D2F7-4A13-BDDE-64ADC8BDD2AFQ52591302-C2AF63CA-D010-4421-8FB4-4FDDD936FCA4Q52642725-61B7C6E4-27DD-4F15-81E9-29C4BBFA20C6Q58716061-E8C7644D-19C5-4564-9E98-276574C24ED2
P2860
Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@ast
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@en
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@nl
type
label
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@ast
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@en
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@nl
prefLabel
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@ast
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@en
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@nl
P2093
P2860
P50
P356
P1476
Toxoplasma gondii Cathepsin L ...... omophenyl-vinyl Sulfone Phenyl
@en
P2093
Angela M Kelley
Ethan A Merritt
Fabiola Parussini
Jonathan D Giebel
My-Hang Huynh
P2860
P304
P356
10.1074/JBC.M109.003780
P407
P577
2009-09-25T00:00:00Z