Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB
about
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodificationIron-catalysed oxidation intermediates captured in a DNA repair dioxygenaseImplications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C LesionsDuplex interrogation by a direct DNA repair protein in search of base damageStructure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylationSwitching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residuesImposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases.Urea-Dependent Adenylate Kinase Activation following Redistribution of Structural States.A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO.Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological ConditionsSchizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histonesProtein dynamics control the progression and efficiency of the catalytic reaction cycle of the Escherichia coli DNA-repair enzyme AlkBX-ray absorption spectroscopy structural investigation of early intermediates in the mechanism of DNA repair by human ABH2.The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.AlkB dioxygenase preferentially repairs protonated substrates: specificity against exocyclic adducts and molecular mechanism of action.Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy.Quantum mechanics/molecular mechanics study on the oxygen binding and substrate hydroxylation step in AlkB repair enzymesNucleic acid oxidation in DNA damage repair and epigeneticsDNA repair by reversal of DNA damage.Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases.Non-homologous functions of the AlkB homologs.5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.Computational investigation of O2 diffusion through an intra-molecular tunnel in AlkB; influence of polarization on O2 transport.Spectroscopic studies of the mononuclear non-heme Fe(II) enzyme FIH: second-sphere contributions to reactivity.Biochemical Characterization of AP Lyase and m6A Demethylase Activities of Human AlkB Homologue 1 (ALKBH1).Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses
P2860
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P2860
Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@ast
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@en
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@nl
type
label
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@ast
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@en
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@nl
prefLabel
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@ast
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@en
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@nl
P2860
P356
P1476
Enzymological and structural s ...... idative DNA repair enzyme AlkB
@en
P2093
John F Hunt
P2860
P304
P356
10.1073/PNAS.0812938106
P407
P577
2009-08-25T00:00:00Z