AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
about
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodificationHuman ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damageHuman AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survivalOxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTOSpectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNARepair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNAIron-catalysed oxidation intermediates captured in a DNA repair dioxygenaseA non-heme iron-mediated chemical demethylation in DNA and RNAAlleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkBThe current state of eukaryotic DNA base damage and repairStructural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNAEnzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkBStructural and Mutational Analysis of Escherichia coli AlkB Provides Insight into Substrate Specificity and DNA Damage SearchingStructure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA systemFlavin-Induced Oligomerization in Escherichia coli Adaptive Response Protein AidBAlkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkBHuman ALKBH4 interacts with proteins associated with transcriptionA chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivoImpaired placental trophoblast lineage differentiation in Alkbh1(-/-) miceGenome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeastNoncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolismRecognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG).Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylationBiological properties of single chemical-DNA adducts: a twenty year perspectiveChemical-biological fingerprinting: probing the properties of DNA lesions formed by peroxynitrite.Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNAOncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions1,3-Butadiene-Induced Adenine DNA Adducts Are Genotoxic but Only Weakly Mutagenic When Replicated in Escherichia coli of Various Repair and Replication BackgroundsSchizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histonesMechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkBRepair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry.Formation and repair of tobacco carcinogen-derived bulky DNA adductsHighly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer riskKinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by AlkA.An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.
P2860
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P2860
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@ast
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@en
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@nl
type
label
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@ast
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@en
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@nl
prefLabel
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@ast
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@en
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@nl
P2093
P2860
P3181
P356
P1476
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
@en
P2093
Catherine L Drennan
Cintyu Wong
James C Delaney
John M Essigmann
John S Wishnok
Koli Taghizadeh
Lauren E Frick
Leona D Samson
P2860
P2888
P304
P3181
P356
10.1038/NSMB996
P407
P577
2005-10-02T00:00:00Z