ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor - Wikidata - wikimedia - TriplyDB

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

http://www.wikidata.org/entity/Q27657234

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Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains A single ligand is sufficient to activate EGFR dimers Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies Conventions and workflows for using Situs Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila.Using Situs for the integration of multi-resolution structures.Palmitoylation: a protein S-acylation with implications for breast cancer.Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity.Functional convergence of signalling by GPI-anchored and anchorless forms of a salamander protein implicated in limb regeneration.Pathogenetic mechanisms in gastric cancer.A conformationally constrained peptidomimetic binds to the extracellular region of HER2 protein The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.Molecular architecture of the ErbB2 extracellular domain homodimer.Regulation of the catalytic activity of the EGF receptor.A structural perspective on the regulation of the epidermal growth factor receptor.Ligand regulation of a constitutively dimeric EGF receptor.Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.Architecture and membrane interactions of the EGF receptor.Effect of acute acid-base disturbances on ErbB1/2 tyrosine phosphorylation in rabbit renal proximal tubules.Transmembrane helix-helix interactions involved in ErbB receptor signaling.Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications.NMR reveals novel mechanisms of protein activity regulation.Spatial regulation of receptor tyrosine kinases in development and cancer.The EGFR family: not so prototypical receptor tyrosine kinases.Molecular dynamics simulations of transitions for ECD epidermal growth factor receptors show key differences between human and drosophila forms of the receptors.Cell membrane gp96 facilitates HER2 dimerization and serves as a novel target in breast cancer.Suppression of heregulin β signaling by the single N-glycan deletion mutant of soluble ErbB3 protein.Ligand binding induces a conformational change in epidermal growth factor receptor dimers.Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family.EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions.ErbB4 Activated p38γ MAPK Isoform Mediates Early Cardiogenesis Through NKx2.5 in Human Pluripotent Stem Cells.

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ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

http://www.wikidata.org/entity/Q27657234

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

@ast

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

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ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

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type

label

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

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ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

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ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

@nl

prefLabel

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

@ast

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

@en

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

@nl

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ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

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Daryl E Klein

http://www.w3.org/2001/XMLSchema#string

Diego Alvarado

http://www.w3.org/2001/XMLSchema#string

P2860

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

Binding of Neu differentiation factor with the extracellular domain of Her2 and Her3

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.

Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structure of the extracellular region of HER3 reveals an interdomain tether

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scholarly article

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10.1038/NATURE08297

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7261

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2762480

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