Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface
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Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domainPhosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell linesEGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatmentThe extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.From combinatorial peptide selection to drug prototype (II): targeting the epidermal growth factor receptor pathwayExpanding the concepts in protein structure-function relationships and enzyme kinetics: Teaching using morpheeinsToward a magic or imaginary bullet? Ligands for drug targeting to cancer cells: principles, hopes, and challengesEnhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancerInhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR SignalingThe Chlamydia pneumoniae invasin protein Pmp21 recruits the EGF receptor for host cell entryContributions of the interdomain loop, amino terminus, and subunit interface to the ligand-facilitated dimerization of neurophysin: Crystal structures and mutation studies of bovine neurophysin-IMatuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for DimerizationErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptorStructural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor ReceptorA single ligand is sufficient to activate EGFR dimersA Sox10 expression screen identifies an amino acid essential for Erbb3 function.Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling PathwayComprehensive assessment of cancer missense mutation clustering in protein structuresEpithelial inflammation resulting from an inherited loss-of-function mutation in EGFRModel-based analysis of HER activation in cells co-expressing EGFR, HER2 and HER3HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cellsTargeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors.Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model systemSialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells.EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerizationTargeting the EGFR signaling pathway in cancer therapy.Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.On the nature of low- and high-affinity EGF receptors on living cells.Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.Development of an epidermal growth factor derivative with EGFR blocking activityRegulation of human EGF receptor by lipidsA transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cellsInhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimicsNovel Peptidomimetics for Inhibition of HER2:HER3 Heterodimerization in HER2-Positive Breast CancerErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding.Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibitionLigand regulation of a constitutively dimeric EGF receptor.HER2 therapy. HER2 (ERBB2): functional diversity from structurally conserved building blocks.Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells.
P2860
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P2860
Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Epidermal growth factor recept ...... changes in the dimer interface
@ast
Epidermal growth factor recept ...... changes in the dimer interface
@en
Epidermal growth factor recept ...... changes in the dimer interface
@en-gb
Epidermal growth factor recept ...... changes in the dimer interface
@nl
type
label
Epidermal growth factor recept ...... changes in the dimer interface
@ast
Epidermal growth factor recept ...... changes in the dimer interface
@en
Epidermal growth factor recept ...... changes in the dimer interface
@en-gb
Epidermal growth factor recept ...... changes in the dimer interface
@nl
prefLabel
Epidermal growth factor recept ...... changes in the dimer interface
@ast
Epidermal growth factor recept ...... changes in the dimer interface
@en
Epidermal growth factor recept ...... changes in the dimer interface
@en-gb
Epidermal growth factor recept ...... changes in the dimer interface
@nl
P2093
P2860
P50
P3181
P1476
Epidermal growth factor recept ...... changes in the dimer interface
@en
P2093
Chun-Chi Lin
Jessica P Dawson
Kathryn M Ferguson
P2860
P304
P3181
P356
10.1128/MCB.25.17.7734-7742.2005
P407
P577
2005-09-01T00:00:00Z