Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors - Wikidata - wikimedia - TriplyDB

Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

http://www.wikidata.org/entity/Q27657436

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Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Computational methods in drug discovery Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).Developing β-secretase inhibitors for treatment of Alzheimer's disease.Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors.Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.In silico studies in drug research against neurodegenerative diseases.New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease.Design, synthesis and evaluation of 3-(2-aminoheterocycle)-4-benzyloxyphenylbenzamide derivatives as BACE-1 inhibitors.Synthesis of substituted 2-aminoimidazoles via Pd-catalyzed alkyne carboamination reactions. Application to the synthesis of preclathridine natural products.Heterocycles in peptidomimetics and pseudopeptides: design and synthesis.Concise and diversity-oriented route toward polysubstituted 2-aminoimidazole alkaloids and their analogues.Microwave-assisted one-pot synthesis and anti-biofilm activity of 2-amino-1H-imidazole/triazole conjugates.Synthesis of amino heterocycle aspartyl protease inhibitors.A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.

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Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

http://www.wikidata.org/entity/Q27657436

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

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2009年论文

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name

Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

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Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

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Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

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type

label

Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

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Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

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Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

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prefLabel

Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

@ast

Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

@en

Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

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Journal of Medicinal Chemistry

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Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors

@en

P2093

Albert J Robichaud

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Andrea Olland

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Erik Wagner

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Iwan Gunawan

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Jim Erdei

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Jim Turner

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Jonathan Bard

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Keith Barnes

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Kristi Fan

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Matthew Johnson

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6314-23

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scholarly article

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88937

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10.1021/JM9006752

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20

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52

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2009-10-22T00:00:00Z

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19757823

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