Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit
about
Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease.Phosphodiesterase 6C, cGMP-specific cone alpha'.Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.The GAFa domain of phosphodiesterase-6 contains a rod outer segment localization signal.Determinants for phosphodiesterase 6 inhibition by its gamma-subunitComplementary interactions of the rod PDE6 inhibitory subunit with the catalytic subunits and transducin.Structural characterization of the rod cGMP phosphodiesterase 6.Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesteraseIn vitro interaction of tubulin with the photoreceptor cGMP phosphodiesterase gamma-subunit.Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent.Molecular architecture of photoreceptor phosphodiesterase elucidated by chemical cross-linking and integrative modelingN-terminal half of the cGMP phosphodiesterase gamma-subunit contributes to stabilization of the GTPase-accelerating protein complexDetergents stabilize the conformation of phosphodiesterase 6.Domain organization and conformational plasticity of the G protein effector, PDE6.Atypical retinal degeneration 3 in mice is caused by defective PDE6B pre-mRNA splicing.Characterization of conformational changes and protein-protein interactions of rod photoreceptor phosphodiesterase (PDE6).Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1).Cone phosphodiesterase-6α' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6β-deficient rd10 mouseExploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.Aryl Hydrocarbon Receptor-interacting Protein-like 1 Is an Obligate Chaperone of Phosphodiesterase 6 and Is Assisted by the γ-Subunit of Its Client.AIPL1: A specialized chaperone for the phototransduction effector.Mechanisms of mutant PDE6 proteins underlying retinal diseases.Congenital Achromatopsia and Macular Atrophy Caused by a Novel Recessive PDE6C Mutation (p.E591K).Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
P2860
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P2860
Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural basis of phosphodie ...... rminal region of the γ-subunit
@ast
Structural basis of phosphodie ...... rminal region of the γ-subunit
@en
Structural basis of phosphodie ...... rminal region of the γ-subunit
@nl
type
label
Structural basis of phosphodie ...... rminal region of the γ-subunit
@ast
Structural basis of phosphodie ...... rminal region of the γ-subunit
@en
Structural basis of phosphodie ...... rminal region of the γ-subunit
@nl
prefLabel
Structural basis of phosphodie ...... rminal region of the γ-subunit
@ast
Structural basis of phosphodie ...... rminal region of the γ-subunit
@en
Structural basis of phosphodie ...... rminal region of the γ-subunit
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structural basis of phosphodie ...... al region of the gamma-subunit
@en
P2093
Brandy Barren
Hakim Muradov
Kimberly K Boyd
S Ramaswamy
P2860
P304
P3181
P356
10.1038/EMBOJ.2009.284
P407
P577
2009-10-01T00:00:00Z