Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
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Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEFR9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1The R7 RGS protein family: multi-subunit regulators of neuronal G protein signalingShedding light on adaptationCrystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3Crystal structure of the multifunctional Gβ5–RGS9 complexIntrinsically disordered -subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structureMolecular architecture of G o and the structural basis for RGS16-mediated deactivationStructural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunitsRecognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEFStructural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunitKinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling ComplexIdentification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain ComplexAn autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activationStructural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq ComplexA Constitutively Active Gα Subunit Provides Insights into the Mechanism of G Protein ActivationBinding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channelsMapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEFG protein signaling: insights from new structures.Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases.Strike a pose: Gαq complexes at the membraneTrp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.RACK1, A multifaceted scaffolding protein: Structure and function.Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution.Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteinsProgressive dry-core-wet-rim hydration trend in a nested-ring topology of protein binding interfaces.Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchangeEvolution of class-specific peptides targeting a hot spot of the Galphas subunit.Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.Allosteric determinants in guanine nucleotide-binding proteins.A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.Complementary interactions of the rod PDE6 inhibitory subunit with the catalytic subunits and transducin.Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signalingObligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPasesStructural characterization of the rod cGMP phosphodiesterase 6.Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesteraseDifferential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent.Evolution of a signaling nexus constrained by protein interfaces and conformational States.
P2860
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P2860
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@ast
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@en
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@nl
type
label
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@ast
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@en
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@nl
prefLabel
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@ast
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@en
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@nl
P2093
P3181
P356
P1433
P1476
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
@en
P2093
P2888
P304
P3181
P356
10.1038/35059138
P407
P577
2001-02-22T00:00:00Z
P6179
1002225654