Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity - Wikidata - wikimedia - TriplyDB

Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

http://www.wikidata.org/entity/Q27658020

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The variable N-terminal region of DDX5 contains structural elements and auto-inhibits its interaction with NS5B of hepatitis C virus Targeting the Eph System with Peptides and Peptide Conjugates Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice Structurally encoded intraclass differences in EphA clusters drive distinct cell responses Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5 Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.Disruption of FAT10-MAD2 binding inhibits tumor progression.Identification and characterization of Nanobodies targeting the EphA4 receptor.Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plants Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease.Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations.Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations.Eph/ephrin interactions modulate vascular sympathetic innervation.HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations Structural principles within the human-virus protein-protein interaction network.A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5.Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor.Eph/ephrin signaling in epidermal differentiation and disease Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion.Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor.Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats.Roles of EphA2 in Development and Disease.Tie2 and Eph receptor tyrosine kinase activation and signaling.Cells under siege: viral glycoprotein interactions at the cell surface.Eph-dependent cell-cell adhesion and segregation in development and cancer.NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.EphA3 biology and cancer.Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions.Protein-Protein Interactions in Virus-Host Systems.Axo-Glia Interaction Preceding CNS Myelination Is Regulated by Bidirectional Eph-Ephrin Signaling.Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation.Sizes of interface residues account for cross-class binding affinity patterns in Eph receptor-ephrin families.Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling.

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Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

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2010 nî lūn-bûn

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2010年の論文

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Structural Characterization of ...... Eph-Ephrin Binding Promiscuity

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JBC.M109.064824

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Journal of Biological Chemistry

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Structural Characterization of ...... Eph-Ephrin Binding Promiscuity

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Elena B Pasquale

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Haina Qin

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Xuelu Huan

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P2860

Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain

Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Crystal structure of an ephrin ectodomain

Crystal structure of an Eph receptor-ephrin complex

Compensating enthalpic and entropic changes hinder binding affinity optimization

Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition

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10.1074/JBC.M109.064824

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1

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285

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Roberta Noberini

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2010-01-01T00:00:00Z

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19875447

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2804212

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