Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors

Item
http://www.wikidata.org/entity/Q27658026
Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsDual Allosteric Inhibitors Jointly Modulate Protein Structure and Dynamics in the Hepatitis C Virus Polymerase.Do Halogen-Hydrogen Bond Donor Interactions Dominate the Favorable Contribution of Halogens to Ligand-Protein Binding?Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C.Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors.Allosteric inhibitors have distinct effects, but also common modes of action, in the HCV polymerase.Classification of HCV NS5B polymerase inhibitors using support vector machine.Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.Methyl Relaxation Measurements Reveal Patterns of Fast Dynamics in a Viral RNA-Directed RNA PolymeraseThumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase.Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: ten years of research.Combination of pharmacophore hypothesis and molecular docking to identify novel inhibitors of HCV NS5B polymerase.Computational predictions suggest that structural similarity in viral polymerases may lead to comparable allosteric binding sites.Molecular simulations to delineate functional conformational transitions in the HCV polymerase.
P2860

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors

Item
http://www.wikidata.org/entity/Q27658026
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identification and biological ...... rus NS5B polymerase inhibitors
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Identification and biological ...... rus NS5B polymerase inhibitors
@en
Identification and biological ...... rus NS5B polymerase inhibitors
@nl
type
label
Identification and biological ...... rus NS5B polymerase inhibitors
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Identification and biological ...... rus NS5B polymerase inhibitors
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Identification and biological ...... rus NS5B polymerase inhibitors
@nl
prefLabel
Identification and biological ...... rus NS5B polymerase inhibitors
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Identification and biological ...... rus NS5B polymerase inhibitors
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Identification and biological ...... rus NS5B polymerase inhibitors
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P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Identification and biological ...... rus NS5B polymerase inhibitors
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698