about
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domainSubstrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complexSelection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric sindbis virusesMultiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virusStructural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with RibonucleotidesSelection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymeraseIn Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide InhibitorAn amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4AActivity of purified hepatitis C virus protease NS3 on peptide substratesComplex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal formNS3 is a serine protease required for processing of hepatitis C virus polyproteinThe solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanismStructural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutantsStructural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitorsIdentification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitorsDiscovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymeraseMetabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activityLFB1/HNF1 acts as a repressor of its own transcriptionThe metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent.NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.Structure and function of the hepatitis C virus NS3-NS4A serine proteinase.Molecular virology of the hepatitis C virus.Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines.Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material.In vitro antibiofilm activity of bioactive glass S53P4.Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis.DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding ProteinMolecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosisOxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.Hepatitis C virus-specific directly acting antiviral drugs.New horizons in hepatitis C antiviral therapy with direct-acting antivirals.Why is it so difficult to develop a hepatitis C virus preventive vaccine?
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
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name
Raffaele De Francesco
@ast
Raffaele De Francesco
@en
Raffaele De Francesco
@es
Raffaele De Francesco
@nl
Raffaele De Francesco
@sl
type
label
Raffaele De Francesco
@ast
Raffaele De Francesco
@en
Raffaele De Francesco
@es
Raffaele De Francesco
@nl
Raffaele De Francesco
@sl
prefLabel
Raffaele De Francesco
@ast
Raffaele De Francesco
@en
Raffaele De Francesco
@es
Raffaele De Francesco
@nl
Raffaele De Francesco
@sl
P108
P1053
J-6003-2012
P106
P108
P1153
7004278557
P21
P31
P3829
P496
0000-0001-8754-5123