Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors - Wikidata - wikimedia - TriplyDB

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

http://www.wikidata.org/entity/Q27658377

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JNK signalling in cancer: in need of new, smarter therapeutic targets Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases Discovery of Potent and Selective Covalent Inhibitors of JNK Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation.Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-hydroxydopamine Model of Parkinson's Disease.Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1).Enzyme kinetics and interaction studies for human JNK1β1 and substrates activating transcription factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun).Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats.Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin's Anorectic Signaling Actions.A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.JNK inhibitors as anti-inflammatory and neuroprotective agents.Nuclear and cytosolic JNK signalling in neurons.Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase.Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway.

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Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

http://www.wikidata.org/entity/Q27658377

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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Synthesis, Biological Evaluati ...... rminal Kinase (JNK) Inhibitors

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Synthesis, Biological Evaluati ...... rminal Kinase (JNK) Inhibitors

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Journal of Medicinal Chemistry

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Synthesis, biological evaluati ...... rminal kinase (JNK) inhibitors

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Claudia H Ruiz

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Derek Duckett

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Jeff Habel

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John D Laughlin

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Li Lin

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Mariana Figuera-Losada

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Michael D Cameron

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Philip V LoGrasso

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Rong Jiang

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Ted Kamenecka

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P2860

p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3

Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors

Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

Coot: model-building tools for molecular graphics

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

Phasercrystallographic software

Refinement of macromolecular structures by the maximum-likelihood method

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419-431

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10.1021/JM901351F

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P433

1

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53

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Jeremy W. Chambers

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2010-01-01T00:00:00Z

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40040737

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19947601

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pharmacokinetics

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2804074

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