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Direct Observation of an Enamine Intermediate in Amine Catalysis

Direct Observation of an Enamine Intermediate in Amine Catalysis

http://www.wikidata.org/entity/Q27658492

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Chemical approaches to detect and analyze protein sulfenic acids Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation Sulfenic acid chemistry, detection and cellular lifetime Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers.Computational strategies for the design of new enzymatic functions A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase Synthesis and evaluation of the aldolase antibody-derived chemical-antibodies targeting α5β1 integrin Chemically programmed antibodies.Chemically Programmed Bispecific Antibodies in Diabody Format.Chemical approaches to discovery and study of sources and targets of hydrogen peroxide redox signaling through NADPH oxidase proteins.Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro.Expanding the concept of chemically programmable antibodies to RNA aptamers: chemically programmed biotherapeutics.Aldolase activity of serum albumins.Positive Effect of Water in Asymmetric Direct Aldol Reactions with Primary Amine Organocatalyst: Experimental and Computational Studies.Merging aerobic oxidation and enamine catalysis in the asymmetric α-amination of β-ketocarbonyls using N-hydroxycarbamates as nitrogen sources.Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme Catalysis Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge

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P2860

Direct Observation of an Enamine Intermediate in Amine Catalysis

http://www.wikidata.org/entity/Q27658492

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Direct Observation of an Enamine Intermediate in Amine Catalysis

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Direct Observation of an Enamine Intermediate in Amine Catalysis

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Direct Observation of an Enamine Intermediate in Amine Catalysis

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Direct Observation of an Enamine Intermediate in Amine Catalysis

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Direct Observation of an Enamine Intermediate in Amine Catalysis

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Direct Observation of an Enamine Intermediate in Amine Catalysis

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Direct Observation of an Enamine Intermediate in Amine Catalysis

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Direct Observation of an Enamine Intermediate in Amine Catalysis

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Direct Observation of an Enamine Intermediate in Amine Catalysis

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P1433

Journal of the American Chemical Society

P1476

Direct Observation of an Enamine Intermediate in Amine Catalysis

@en

P2093

Carlos F Barbas

http://www.w3.org/2001/XMLSchema#string

Ian A Wilson

http://www.w3.org/2001/XMLSchema#string

Richard A Lerner

http://www.w3.org/2001/XMLSchema#string

Xueyong Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanism of the Class I KDPG aldolase

De novo computational design of retro-aldol enzymes

Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-A resolution

Observation of covalent intermediates in an enzyme mechanism at atomic resolution

Stereospecific proton transfer by a mobile catalyst in mammalian fructose-1,6-bisphosphate aldolase

The origin of the electrostatic perturbation in acetoacetate decarboxylase

Immune versus natural selection: antibody aldolases with enzymic rates but broader scope

Enamine-based organocatalysis with proline and diamines: the development of direct catalytic asymmetric Aldol, Mannich, Michael, and Diels-alder reactions.

Reactive immunization: a unique approach to catalytic antibodies.

Organocatalysis--after the gold rush.

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18206-7

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scholarly article

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10.1021/JA907271A

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51

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131

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2009-12-30T00:00:00Z

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40455199

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19968282

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P921

4-[4-(3,5-dioxohexyl)phenylcarbamoyl]butyric acid

P932

3227542

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