De novo computational design of retro-aldol enzymes - Wikidata - wikimedia - TriplyDB

De novo computational design of retro-aldol enzymes

De novo computational design of retro-aldol enzymes

http://www.wikidata.org/entity/Q24609401

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Computational enzyme design approaches with significant biological outcomes: progress and challenges Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymes Beyond directed evolution--semi-rational protein engineering and design Increased Diels-Alderase activity through backbone remodeling guided by Foldit players.Exploring protein fitness landscapes by directed evolution Design and engineering of an O(2) transport protein Computational design of Candida boidinii xylose reductase for altered cofactor specificity The farther, the safer: a manifesto for securely navigating synthetic species away from the old living world Consensus protein design Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity Protein stability: computation, sequence statistics, and new experimental methods Engineering oxidoreductases: maquette proteins designed from scratch Protein design: toward functional metalloenzymes Shedding light on protein folding, structural and functional dynamics by single molecule studies A new paradigm of DNA synthesis: three-metal-ion catalysis.Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole Using affinity chromatography to engineer and characterize pH-dependent protein switches Establishing wild-type levels of catalytic activity on natural and artificial ( )8-barrel protein scaffolds The pKa Values of Acidic and Basic Residues Buried at the Same Internal Location in a Protein Are Governed by Different Factors Alteration of enzyme specificity by computational loop remodeling and design Structural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface Evolution Computational design of ligand binding is not a solved problem An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket Rational design of a structural and functional nitric oxide reductase Direct Observation of an Enamine Intermediate in Amine Catalysis Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion hole Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin Predicting resistance mutations using protein design algorithms Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution Computational design of an endo-1,4- -xylanase ligand binding site Computational Design of Virus-Like Protein Assemblies on Carbon Nanotube Surfaces Computational Design of Catalytic Dyads and Oxyanion Holes for Ester Hydrolysis Novel Conformation of an RNA Structural Switch Principles for designing ideal protein structures Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design Structural Insights into the Recovery of Aldolase Activity inN-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis Strategy Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis Iterative approach to computational enzyme design Evolution of a designed retro-aldolase leads to complete active site remodeling

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De novo computational design of retro-aldol enzymes

http://www.wikidata.org/entity/Q24609401

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

De novo computational design of retro-aldol enzymes

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De novo computational design of retro-aldol enzymes

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De novo computational design of retro-aldol enzymes

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type

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De novo computational design of retro-aldol enzymes

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De novo computational design of retro-aldol enzymes

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De novo computational design of retro-aldol enzymes

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De Novo Computational Design of Retro-Aldol Enzymes

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prefLabel

De novo computational design of retro-aldol enzymes

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De novo computational design of retro-aldol enzymes

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De novo computational design of retro-aldol enzymes

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De novo computational design of retro-aldol enzymes

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Alexandre Zanghellini

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Barry L Stoddard

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Carlos F Barbas

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Daniela Röthlisberger

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Donald Hilvert

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Eric A Althoff

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Fernando R Clemente

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Jamie L Betker

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Jasmine L Gallaher

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Kendall N Houk

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

Mechanism of the Class I KDPG aldolase

Observation of covalent intermediates in an enzyme mechanism at atomic resolution

The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data

Computational design of receptor and sensor proteins with novel functions.

A modular assembly strategy for improving the substrate specificity of small catalytic peptides.

Evolution of aldolase antibodies in vitro: correlation of catalytic activity and reaction-based selection.

Selection and evolution of enzymes from a partially randomized non-catalytic scaffold.

Directed evolution of biocatalysts.

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319

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Daniela Röthlisberger

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