Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy

Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy

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http://www.wikidata.org/entity/Q27658896
Crystal structure of human cyclin-dependent kinase-2 complex with MK2 inhibitor TEI-I01800: insight into the selectivityStructure of the β-form of human MK2 in complex with the non-selective kinase inhibitor TEI-L03090Classification of scaffold-hopping approachesThe p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical TrialsApproaches towards the synthesis of 5-aminopyrazoles.Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors.Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells.A computational study on thiourea analogs as potent MK-2 inhibitors.The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation.Binding affinity prediction for ligands and receptors forming tautomers and ionization species: inhibition of mitogen-activated protein kinase-activated protein kinase 2 (MK2).Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure.
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Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy

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http://www.wikidata.org/entity/Q27658896
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2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@ast
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@en
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@nl
type
label
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@ast
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@en
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@nl
prefLabel
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@ast
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@en
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@nl
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Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2009.10.138
P407
P433
P478
P50
P577
P698