about
IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial ImmunophilinsKnowledge-based fragment binding predictionProgress in the analysis of multiple activity profile of screening data using computational approaches.2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological EvaluationDeterminants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds.Computational studies to predict or explain G protein coupled receptor polypharmacologyNetwork measures for chemical library design.Structural diversity and potency range distribution of scaffolds from compounds active against current pharmaceutical targets.Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors.Carbonyl J acid derivatives block protein priming of hepadnaviral P protein and DNA-dependent DNA synthesis activity of hepadnaviral nucleocapsids.Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Predicting protein-ligand affinity with a random matrix framework.QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni.Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteresPyrazolo[3,4-b]pyridine kinase inhibitors: a patent review (2008--present).The chemistry and biology of soluble guanylate cyclase stimulators and activators.ASDB: a resource for probing protein functions with small molecules.Computational functional group mapping for drug discovery.Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion.The Isoxazole Ring and Its N-Oxide: A Privileged Core Structure in Neuropsychiatric Therapeutics.Activity Landscapes, Information Theory, and Structure - Activity Relationships.Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial AgentsIs computer-assisted rescaffolding the future in lead generation?Scaffold-Hopping of Aurones: 2-Arylideneimidazo[1,2-a]pyridinones as Topoisomerase IIα-Inhibiting Anticancer Agents.Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors.Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Agrochemical lead optimization by scaffold hopping.Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy.Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors.Design, Synthesis and Biological Evaluation of Stilbene Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B.Identifying Activity Cliff Generators of PPAR Ligands Using SAS Maps.Computer-Aided Drug Design in Epigenetics.
P2860
Q27675276-23E75A19-D0E9-44FE-8CEA-3F344EEC0901Q27681063-2755F486-FFA6-48DF-8E22-ECE42DCFFFFCQ28538204-5EC0EE3F-0591-4B78-8FA6-81FA9F9B1F76Q30845109-848F0B29-C122-4060-B7E9-4947F567FB51Q33636453-463F2939-001E-43AA-A925-F13A3C8A2AE8Q34313816-5A942BA3-B5FD-4E55-B8F5-94A3D0CDC3C0Q35039998-F9597A1B-1336-459B-87FB-A69BCD6597E1Q35241159-6CD98EF4-5149-4C3C-AEAE-6536C46EFBD1Q35562106-C230A51E-14DA-4178-B7F5-5D22698E20ACQ35671797-2C57662F-458A-46C6-BDB6-9B1EBDCD8853Q36246202-1F208299-A51E-4DA6-859C-6757A0DA8797Q36372894-AF0F615E-EDF2-4DFA-8B61-179AFBFE8618Q37473901-60A7B3D9-4EFE-48D4-A418-89E0008D2D3CQ37616239-CB06ABF7-0DC7-467B-B6F4-E14EDB3E07E0Q37632881-DB63B455-23FF-4DAF-970A-455DF8986AC7Q38071651-F4FEA864-0D97-4A1F-A15C-399858D13647Q38130465-49F1BD9E-F640-4AFF-BB29-368F763A7762Q38396600-DD5B0165-A180-4458-9298-A9385F9DE7FBQ38890648-5FF6C7ED-4D91-4282-87DF-7E4569EAE10DQ38976602-5F713C16-6BD5-4981-8BA7-86808447F2ADQ39157903-2B3781A3-CBAE-4F53-8776-F3E6BDA2B1E4Q39535358-A483B203-6495-48F4-A013-F4E9A13622E8Q40809010-E027296E-225B-4A7C-8120-4DE4B159E4D2Q41870937-F228C7C1-D9E5-40FB-9292-05DA085B4CFEQ44460652-B3D1D6EC-8933-4987-9166-E8BB60DA7323Q46732620-1B3B8583-B8EB-4DE8-B7B4-2CE26EC624A8Q48117853-775D2A76-9CF9-40F4-BFCF-5FC8D07FB1CDQ48120802-59D195F3-E163-4AF5-92FE-6E664A7D3DB6Q48221772-514FD7E3-D17B-412A-B222-BBAA6FFE1667Q48507411-EA72E3E2-5E76-4776-9CE5-20A4B678014FQ50997819-C824B88B-D64E-43B2-A3F1-A584A8F04415Q51070838-9344C7C5-9C89-4CBC-8EFC-86106EE7D00DQ51604040-D80A5ECD-B09E-40A8-9B9C-30BE9A0C1D50Q55120002-F2734F20-1B7C-4C99-AD69-8DC06ED1B075
P2860
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Classification of scaffold-hopping approaches
@ast
Classification of scaffold-hopping approaches
@en
type
label
Classification of scaffold-hopping approaches
@ast
Classification of scaffold-hopping approaches
@en
prefLabel
Classification of scaffold-hopping approaches
@ast
Classification of scaffold-hopping approaches
@en
P2860
P1433
P1476
Classification of scaffold-hopping approaches
@en
P2093
Gregory Tawa
Hongmao Sun
P2860
P304
P356
10.1016/J.DRUDIS.2011.10.024
P577
2011-10-26T00:00:00Z