Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium - Wikidata - wikimedia - TriplyDB

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

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Calcium-dependent protein kinases: hubs in plant stress signaling and development Calcium and reactive oxygen species rule the waves of signaling The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp TgCDPK3 regulates calcium-dependent egress of Toxoplasma gondii from host cells The Cryptosporidium parvum Kinome Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1 Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy Biochemical characterization of FIKK8--A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans A forward genetic screen reveals that calcium-dependent protein kinase 3 regulates egress in Toxoplasma Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.A rice calcium-dependent protein kinase is expressed in cortical root cells during the presymbiotic phase of the arbuscular mycorrhizal symbiosis.Distinct signalling pathways control Toxoplasma egress and host-cell invasion Impact of Ca(2+) on structure of soybean CDPKβ and accessibility of the Tyr-24 autophosphorylation site The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival.Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa.How apicomplexan parasites move in and out of cells.Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii The evolutionary history and diverse physiological roles of the grapevine calcium-dependent protein kinase gene family.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Allosteric activation of apicomplexan calcium-dependent protein kinases.Calcium-dependent protein kinases from Arabidopsis show substrate specificity differences in an analysis of 103 substrates The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD.Characterization and Comparison of the CPK Gene Family in the Apple (Malus × domestica) and Other Rosaceae Species and Its Response to Alternaria alternata Infection Novel insights into the regulation of malarial calcium-dependent protein kinase 1 A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs.Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.Calcium signaling and biotic defense responses in plants.Molecular Characterization and Functional Analysis of a Novel Calcium-Dependent Protein Kinase 4 from Eimeria tenella Rice calcium-dependent protein kinase OsCPK17 targets plasma membrane intrinsic protein and sucrose-phosphate synthase and is required for a proper cold stress response.SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.CDPKs in immune and stress signaling αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.Analysis of Noncanonical Calcium-Dependent Protein Kinases in Toxoplasma gondii by Targeted Gene Deletion Using CRISPR/Cas9.Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates.

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Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

http://www.wikidata.org/entity/Q27661204

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Structures of apicomplexan cal ...... anism of activation by calcium

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Structures of apicomplexan cal ...... anism of activation by calcium

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Structures of apicomplexan cal ...... anism of activation by calcium

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Structures of apicomplexan cal ...... anism of activation by calcium

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Structures of apicomplexan cal ...... anism of activation by calcium

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Nature Structural & Molecular Biology

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Structures of apicomplexan cal ...... anism of activation by calcium

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Amy K Wernimont

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Farrell Mackenzie

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Irene Chau

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Jennifer D Artz

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Mehrnaz Amani

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Patrick Finerty

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Raymond Hui

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Sebastian Lourido

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Yu-Hui Lin

http://www.w3.org/2001/XMLSchema#string

P2860

Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi.

Structural basis for the autoinhibition of c-Abl tyrosine kinase

Calmodulin structure refined at 1.7 A resolution

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii

Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures

SOLVE and RESOLVE: automated structure solution, density modification and model building

Coot: model-building tools for molecular graphics

Dissection of mechanisms involved in the regulation of Plasmodium falciparum calcium-dependent protein kinase 4

The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation.

Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme.

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596-601

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scholarly article

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1598636

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10.1038/NSMB.1795

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5

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17

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Guillermo Senisterra

Abdellah Allali-Hassani

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2010-05-01T00:00:00Z

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43535432

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1027338609

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20436473

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protein structure

structural biology

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3675764

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