Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity
about
The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-terminiStructural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1The functions of TRPP2 in the vascular systemA polycystin-centric view of cyst formation and disease: the polycystins revisitedPolycystin-1: a master regulator of intersecting cystic pathwaysStructure and calcium-binding studies of calmodulin-like domain of human non-muscle α-actinin-1.The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 functionA high-resolution structure of the EF-hand domain of human polycystin-2Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutantMolecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopyDeterminants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A.Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites.Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding propertiesIntracellular calcium release modulates polycystin-2 trafficking.Structural biology of TRP channels.Polycystin-2 (TRPP2) Regulation by Ca(2+) Is Effected and Diversified by Actin-Binding ProteinsCalcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating.Ion channels in renal disease.An explicit formulation approach for the analysis of calcium binding to EF-hand proteins using isothermal titration calorimetry.Polycystins and cellular Ca2+ signaling.Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2.Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease.The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.Decrypting the Heat Activation Mechanism of TRPV1 Channel by Molecular Dynamics Simulation.Ca2+ Regulation of TRP Ion Channels.X-ray crystallography of TRP channels.Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity.Structural biology of TRP channels
P2860
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P2860
Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structure of the EF-hand domai ...... polycystin-2 channel activity
@ast
Structure of the EF-hand domai ...... polycystin-2 channel activity
@en
Structure of the EF-hand domai ...... polycystin-2 channel activity
@nl
type
label
Structure of the EF-hand domai ...... polycystin-2 channel activity
@ast
Structure of the EF-hand domai ...... polycystin-2 channel activity
@en
Structure of the EF-hand domai ...... polycystin-2 channel activity
@nl
prefLabel
Structure of the EF-hand domai ...... polycystin-2 channel activity
@ast
Structure of the EF-hand domai ...... polycystin-2 channel activity
@en
Structure of the EF-hand domai ...... polycystin-2 channel activity
@nl
P2093
P2860
P3181
P356
P1476
Structure of the EF-hand domai ...... polycystin-2 channel activity
@en
P2093
Andjelka Celic
Barbara E Ehrlich
Michael E Hodsdon
Scott D Kennedy
Titus J Boggon
P2860
P304
P3181
P356
10.1073/PNAS.0912295107
P407
P577
2010-05-03T00:00:00Z