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Polycystin-1: a master regulator of intersecting cystic pathways

Polycystin-1: a master regulator of intersecting cystic pathways

http://www.wikidata.org/entity/Q26826955

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Polycystic liver diseases: advanced insights into the molecular mechanisms Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic disease Altered trafficking and stability of polycystins underlie polycystic kidney disease.Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells.Ouabain Enhances ADPKD Cell Apoptosis via the Intrinsic Pathway.Genetics and pathogenesis of autosomal dominant polycystic kidney disease: 20 years on.Ciliary subcompartments and cysto-proteins.Tesevatinib ameliorates progression of polycystic kidney disease in rodent models of autosomal recessive polycystic kidney disease.Isolated polycystic liver disease genes define effectors of polycystin-1 function.Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease.B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease.PKD2-Related Autosomal Dominant Polycystic Kidney Disease: Prevalence, Clinical Presentation, Mutation Spectrum, and Prognosis.Recent Trends in ADPKD Research.Emerging Therapies for Childhood Polycystic Kidney Disease.Animal models of biliary injury and altered bile acid metabolism.Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis.The diagnostic value of microRNA-4787-5p and microRNA-4306 in patients with acute aortic dissection.Chromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes.A non-coding variant in GANAB explains isolated polycystic liver disease (PCLD) in a large family.Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling.Genetic Complexity of Autosomal Dominant Polycystic Kidney and Liver Diseases.Epithelial Organization: The Gut and Beyond.Deletion of Pkd1 in renal stromal cells causes defects in the renal stromal compartment and progressive cystogenesis in the kidney.The Genetic and Cellular Basis of Autosomal Dominant Polycystic Kidney Disease-A Primer for Clinicians.Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease.Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.Clinical Features of 167 Inpatients with Autosomal Dominant Polycystic Kidney Disease at a Single Center in China

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Polycystin-1: a master regulator of intersecting cystic pathways

http://www.wikidata.org/entity/Q26826955

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Polycystin-1: a master regulator of intersecting cystic pathways

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Polycystin-1: a master regulator of intersecting cystic pathways

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Polycystin-1: a master regulator of intersecting cystic pathways

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Polycystin-1: a master regulator of intersecting cystic pathways

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Polycystin-1: a master regulator of intersecting cystic pathways

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Polycystin-1: a master regulator of intersecting cystic pathways

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Polycystin-1: a master regulator of intersecting cystic pathways

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Polycystin-1: a master regulator of intersecting cystic pathways

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P356

J.MOLMED.2014.01.004

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Trends in Molecular Medicine

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Polycystin-1: a master regulator of intersecting cystic pathways

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P2093

Anna-Rachel Gallagher

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Sorin V. Fedeles

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Stefan Somlo

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P2860

Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease.

Identification of a locus for autosomal dominant polycystic liver disease, on chromosome 19p13.2-13.1

Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity

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251-60

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10.1016/J.MOLMED.2014.01.004

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