Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator
about
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligandsObservation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitorKinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures surveyA new family of bioorthogonally applicable fluorogenic labels.Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesisChemical biology applied to the study of bacterial pathogens.A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR.Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in miceAdvances In Mycobacterium Tuberculosis Therapeutics Discovery Utlizing Structural Biology.The TetR family of regulators.Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis.New insights into the kinetic target-guided synthesis of protein ligands.Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.AceDRG: a stereochemical description generator for ligands.Probing the binding site of abl tyrosine kinase using in situ click chemistry.Structural and docking studies of potent ethionamide boosters.Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.Synthesis of allene triazole through iron catalyzed regioselective addition to propargyl alcohols.Reaction site-driven regioselective synthesis of AChE inhibitors.New active leads for tuberculosis booster drugs by structure-based drug discovery.Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.N-(furan-2-ylmethyl)-N-methylprop-2-yn-1-amine (F2MPA): A potential cognitive enhancer with MAO inhibitor properties.Optimising in situ click chemistry: the screening and identification of biotin protein ligase inhibitorsClick chemistry inspired synthesis of piperazine-triazole derivatives and evaluation of their antimicrobial activities
P2860
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P2860
Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Exploring drug target flexibil ...... rial transcriptional regulator
@ast
Exploring drug target flexibil ...... rial transcriptional regulator
@en
Exploring drug target flexibil ...... rial transcriptional regulator
@nl
type
label
Exploring drug target flexibil ...... rial transcriptional regulator
@ast
Exploring drug target flexibil ...... rial transcriptional regulator
@en
Exploring drug target flexibil ...... rial transcriptional regulator
@nl
prefLabel
Exploring drug target flexibil ...... rial transcriptional regulator
@ast
Exploring drug target flexibil ...... rial transcriptional regulator
@en
Exploring drug target flexibil ...... rial transcriptional regulator
@nl
P2093
P50
P356
P1433
P1476
Exploring drug target flexibil ...... rial transcriptional regulator
@en
P2093
Bertrand Dirié
Nicolas Willand
Patrick Toto
P304
P356
10.1021/CB100177G
P577
2010-11-19T00:00:00Z