Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

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Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

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Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

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Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

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Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

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Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

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Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

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P1476

Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry

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P2093

Brendan N McConnell

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Daniel Shiu-Hin Chan

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P2860

Native Mass Spectrometry in Fragment-Based Drug Discovery

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches

Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination

The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase

EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator

InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II

P304

7488-7491

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P31

scholarly article

P356

10.1002/ANIE.201702888

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P407

English

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P478

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P50

Dijana Matak-Vinković

P577

2017-05-31T00:00:00Z

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P698

28513917

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