Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism

Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism

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http://www.wikidata.org/entity/Q27664248
Active site profiling reveals coupling between domains in SRC-family kinasesSH3 domains: modules of protein-protein interactions.Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM.The SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function.Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitmentDivergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Structure, dynamics, and Hck interaction of full-length HIV-1 Nef.Viral proteins and Src family kinases: Mechanisms of pathogenicity from a "liaison dangereuse".Computational study of the W260A activating mutant of Src tyrosine kinase.Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex.Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.A selective NMR probe to monitor the conformational transition from inactive to active kinase.Genetic Variants in STAT3 Promoter Regions and Their Application in Molecular Breeding for Body Size Traits in Qinchuan Cattle.The SRC-family tyrosine kinase HCK shapes the landscape of SKAP2 interactome.
P2860

Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism

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http://www.wikidata.org/entity/Q27664248
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2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@ast
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@en
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@nl
type
label
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@ast
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@en
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@nl
prefLabel
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@ast
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@en
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Crystal Structure of the Src F ...... -dominant Activation Mechanism
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932