Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
about
M2 protein from influenza A: from multiple structures to biophysical and functional insightsViral Membrane Channels: Role and Function in the Virus Life CycleStructural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza virusesNMR structures of polytopic integral membrane proteins.Mutations in the membrane-proximal region of the influenza A virus M2 protein cytoplasmic tail have modest effects on virus replication.Magic angle spinning and oriented sample solid-state NMR structural restraints combine for influenza a M2 protein functional insights.Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N).Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel.Effect of cytosolic pH on inward currents reveals structural characteristics of the proton transport cycle in the influenza A protein M2 in cell-free membrane patches of Xenopus oocytesM2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes.Dynamic Short Hydrogen Bonds in Histidine Tetrad of Full-Length M2 Proton Channel Reveal Tetrameric Structural Heterogeneity and Functional MechanismBeyond Structural Biology to Functional Biology: Solid-State NMR Experiments and Strategies for Understanding the M2 Proton Channel Conductance.Structural Influences: Cholesterol, Drug, and Proton Binding to Full-Length Influenza A M2 Protein.Identifying inter-residue resonances in crowded 2D (13)C- (13)C chemical shift correlation spectra of membrane proteins by solid-state MAS NMR difference spectroscopyInfluences of membrane mimetic environments on membrane protein structures.Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.Exploring Histidine Conformations in the M2 Channel Lumen of the Influenza A Virus at Neutral pH via Molecular SimulationsHelical membrane protein conformations and their environmentActivation and proton transport mechanism in influenza A M2 channelThe minimalist architectures of viroporins and their therapeutic implications.iNR-Drug: predicting the interaction of drugs with nuclear receptors in cellular networking.A view into the blind spot: solution NMR provides new insights into signal transduction across the lipid bilayer.Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.Kinetic analysis of the M2 proton conduction of the influenza virus.Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody.The functional heart of the M2 channelSlow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses.The Molecular Switch of Telomere Phages: High Binding Specificity of the PY54 Cro Lytic Repressor to a Single Operator Site.Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.Structural biology. The flu's proton escort.3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.Co-evolution analysis to predict protein-protein interactions within influenza virus envelope.Small variations between species/subtypes attributed to reassortment evidenced from polymerase basic protein 1 with other seven proteins from influenza a virus.GPCR-2L: predicting G protein-coupled receptors and their types by hybridizing two different modes of pseudo amino acid compositions.Fast Atomic Charge Calculation for Implementation into a Polarizable Force Field and Application to an Ion Channel Protein
P2860
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P2860
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
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2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@ast
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@en
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@nl
type
label
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@ast
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@en
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@nl
prefLabel
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@ast
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@en
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@nl
P2860
P1476
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
@en
P2093
James J Chou
Rafal M Pielak
P2860
P356
10.1016/J.BBRC.2010.09.008
P407
P577
2010-10-08T00:00:00Z