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Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

http://www.wikidata.org/entity/Q27665290

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Phosphoinositides: tiny lipids with giant impact on cell regulation Signal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signaling Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation Full-length Gαq–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex A P-loop Mutation in Gα Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes The phospholipase C isozymes and their regulation De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy Strike a pose: Gαq complexes at the membrane Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work Mutations affecting G-protein subunit α11 in hypercalcemia and hypocalcemia Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.An intact helical domain is required for Gα14 to stimulate phospholipase Cβ Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ Phospholipase Cβ1 induces membrane tubulation and is involved in caveolae formation.Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency.The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling Nanobodies to Study G Protein-Coupled Receptor Structure and Function.Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.G protein signaling in the parasite Entamoeba histolytica γ-Synuclein interacts with phospholipase Cβ2 to modulate G protein activation.Membrane-induced allosteric control of phospholipase C-β isozymes.Molecular mechanisms of phospholipase C β3 autoinhibition.Phospholipase C-β in immune cells.Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane.Membrane potential and Ca2+ concentration dependence on pressure and vasoactive agents in arterial smooth muscle: A model.Role of phospholipase Cε in physiological phosphoinositide signaling networks.Protein Gq modulates termination of phototransduction and prevents retinal degeneration.Structural basis for calcium and phosphatidylserine regulation of phospholipase C δ1 Drosophila visual transduction.Angiotensin Converting Enzyme Regulates Cell Proliferation and Migration.Constitutional chromothripsis involving the critical region of 9q21.13 microdeletion syndrome Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs.Crystallization, optimization and preliminary X-ray characterization of a metal-dependent PI-PLC from Streptomyces antibioticus.Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.

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Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

http://www.wikidata.org/entity/Q27665290

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

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Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

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Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

@nl

type

label

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

@ast

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

@en

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

@nl

prefLabel

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

@ast

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

@en

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

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SCIENCE.1193438

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Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

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Gary L Waldo

http://www.w3.org/2001/XMLSchema#string

Kazuhito Tsuboi

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Matthew L Cheever

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Stephanie N Hicks

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T Kendall Harden

http://www.w3.org/2001/XMLSchema#string

Takeharu Kawano

http://www.w3.org/2001/XMLSchema#string

Tiffany K Ricks

http://www.w3.org/2001/XMLSchema#string

Tohru Kozasa

http://www.w3.org/2001/XMLSchema#string

Xiaoyue Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

Molecular architecture of G o and the structural basis for RGS16-mediated deactivation

General and Versatile Autoinhibition of PLC Isozymes

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

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974-80

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scholarly article

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10.1126/SCIENCE.1193438

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330

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2010-11-12T00:00:00Z

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20966218

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