Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
about
A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7The role of ubiquitylation in immune defence and pathogen evasionDeconstructing innate immune signaling in myelodysplastic syndromesUbiquitin in the immune systemRegulation of NF-κB by ubiquitinationStructure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysisSpecific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulationAn ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chainsDeubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cellsA disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activitySecondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activityA novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1Molecular basis for specificity of the Met1-linked polyubiquitin signalSmall changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and diseaseMolecular control of steady-state dendritic cell maturation and immune homeostasis.Mechanisms of generating polyubiquitin chains of different topology.Ubiquitin makes its mark on immune regulation.Protein ubiquitination in lymphoid malignancies.Crystal structure of a complex of NOD1 CARD and ubiquitin.The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages.Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis.A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomesThe ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosisLys63-linked ubiquitin chain adopts multiple conformational states for specific target recognitionK63-linked ubiquitination in kinase activation and cancer.The role of A20 in the pathogenesis of lymphocytic malignancy.Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease.A20: linking a complex regulator of ubiquitylation to immunity and human diseaseLoss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory diseaseMolecular basis of NF-κB signalingDistinct phylogenetic relationships and biochemical properties of Arabidopsis ovarian tumor-related deubiquitinases support their functional differentiation.Regulation of NF-κB signaling by the A20 deubiquitinase.Regulation of NF-κB by deubiquitinases.Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains.Regulation of VEGF signaling by membrane traffic.Regulation of proteolysis by human deubiquitinating enzymes.Deubiquitylases from genes to organism.The deubiquitinase A20 in immunopathology of autoimmune diseases.Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes.Deubiquitinases and the new therapeutic opportunities offered to cancer.
P2860
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P2860
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@ast
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@en
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@nl
type
label
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@ast
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@en
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@nl
prefLabel
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@ast
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@en
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@nl
P2093
P3181
P1433
P1476
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling
@en
P2093
Borlan Pan
Brigitte Maurer
Christine Yu
Cynthia Lam
David Arnott
Ingrid E Wertz
Ivan Bosanac
Lilian Phu
Sarah G Hymowitz
P304
P3181
P356
10.1016/J.MOLCEL.2010.10.009
P577
2010-11-24T00:00:00Z