about
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagyDeubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondriaOTUB1 modulates c-IAP1 stability to regulate signalling pathwaysRibosome binding of a single copy of the SecY complex: implications for protein translocationUbiquitin chain editing revealed by polyubiquitin linkage-specific antibodiesUbiquitin binding to A20 ZnF4 is required for modulation of NF-κB signalingModulation of K11-linkage formation by variable loop residues within UbcH5AConformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signalingUbiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions.Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domainUbiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signalingCharacterizing ubiquitination sites by peptide-based immunoaffinity enrichment.Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes.PIASy-dependent SUMOylation regulates DNA topoisomerase IIalpha activity.A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation.A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834Extended ubiquitin species are protein-based DUB inhibitors.APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1Proteomic insights into ubiquitin and ubiquitin-like proteins.HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome.Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibitionLoss of the tumor suppressor BAP1 causes myeloid transformation.Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.A Biologist's Field Guide to Multiplexed Quantitative Proteomics.Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.Immunoaffinity enrichment coupled to quantitative mass spectrometry reveals ubiquitin-mediated signaling events.Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition.Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death.c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking.Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome.NeuCode Proteomics Reveals Bap1 Regulation of Metabolism.Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Donald S Kirkpatrick
@ast
Donald S Kirkpatrick
@en
Donald S Kirkpatrick
@es
Donald S Kirkpatrick
@sl
type
label
Donald S Kirkpatrick
@ast
Donald S Kirkpatrick
@en
Donald S Kirkpatrick
@es
Donald S Kirkpatrick
@sl
altLabel
Don Kirkpatrick
@en
prefLabel
Donald S Kirkpatrick
@ast
Donald S Kirkpatrick
@en
Donald S Kirkpatrick
@es
Donald S Kirkpatrick
@sl
P106
P21
P31
P496
0000-0003-3091-2804